Роль изменений в структуре и динамике хроматина при covid-19

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Пандемия COVID-19 стала серьезным вызовом для систем здравоохранения и экономики многих государств, а понимание молекулярных механизмов патогенеза этого заболевания явилось значительным вызовом для современной науки. В то же время ученым впервые был доступен ряд высокоточных и высокопроизводительных методов анализа молекулярных процессов, включая технологии исследования изменений в хроматине на геномном уровне. В настоящем обзоре обсуждаются различные современные методы, которые применялись или могут быть применены для изучения изменений в структуре и динамике хроматина при инфицировании SARS-CoV-2, излагаются результаты имеющихся на данный момент исследований о роли этих изменений в патогенезе COVID-19 и в заключение рассматриваются известные на сегодняшний день молекулярные механизмы модуляции работы хроматина, возникающие при инфицировании SARS-CoV-2.

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А. Е. Бигильдеев

Национальный медицинский исследовательский центр гематологии

Автор, ответственный за переписку.
Email: shaytan_ak@mail.bio.msu.ru
Россия, Москва

В. И. Алексеев

Московский государственный университет им. М.В. Ломоносова, биологический факультет

Email: shaytan_ak@mail.bio.msu.ru
Россия, Москва

А. К. Грибкова

Московский государственный университет им. М.В. Ломоносова, биологический факультет

Email: shaytan_ak@mail.bio.msu.ru
Россия, Москва

Г. С. Тимохин

Высшая школа экономики, Международная лаборатория биоинформатики, факультет компьютерных наук

Email: shaytan_ak@mail.bio.msu.ru
Россия, Москва

Г. А. Комарова

Московский государственный университет им. М.В. Ломоносова, физический факультет

Email: shaytan_ak@mail.bio.msu.ru
Россия, Москва

А. К. Шайтан

Московский государственный университет им. М.В. Ломоносова, биологический факультет; Высшая школа экономики, Международная лаборатория биоинформатики, факультет компьютерных наук

Email: shaytan_ak@mail.bio.msu.ru
Россия, Москва; Москва

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