Changes in the Population of Immature Neurons in the Pyriform Cortex of Experimental Animals after Early Life Stress

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Abstract

Early life stress is an important factor predisposing to the development of pathology of the nervous system in animals and humans in the late period of ontogenesis. We used an early life stress model to assess the activation of the piriform cortex upon presentation of olfactory stimuli in experimental animals (CD1 mice, P60 and 10 months old) as well as to assess the expression of markers of neurons with prolonged immaturity involved in the processes of plasticity of the adult brain and its recovery. We found that early life stress reduces the number of immature neurons with the DCX+PSA-NCAM+ phenotype in the piriform cortex and the response to olfactory memory induction. In addition, olfactory stimulation reduces sensitivity to unpleasant stimuli at a young age (P60), stimulates short-term memory. However, at the age of 10 months, these effects are less evident. The results obtained indicate a possible contribution of immature neurons of the piriform cortex to the mechanisms of aberrant neuroplasticity after early life stress.

About the authors

A. B. Salmina

Research Institute of Molecular Medicine and Pathobiochemistry, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Brain Science Institute, Research Center of Neurology

Email: yulia.uspenskaya@mail.ru
Russia, 660022, Krasnoyarsk; Russia, 125367, Moscow

Yu. A. Uspenskaya

Krasnoyarsk State Agrarian University

Author for correspondence.
Email: yulia.uspenskaya@mail.ru
Russia, 660049, Krasnoyarsk

Yu. A. Panina

Research Institute of Molecular Medicine and Pathobiochemistry, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: yulia.uspenskaya@mail.ru
Russia, 660022, Krasnoyarsk; Russia, 660022, Krasnoyarsk

Ya. V. Gorina

Research Institute of Molecular Medicine and Pathobiochemistry, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: yulia.uspenskaya@mail.ru
Russia, 660022, Krasnoyarsk; Russia, 660022, Krasnoyarsk

O. L. Lopatina

Department of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: yulia.uspenskaya@mail.ru
Russia, 660022, Krasnoyarsk

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Copyright (c) 2023 А.Б. Салмина, Ю.А. Успенская, Ю.А. Панина, Я.В. Горина, О.Л. Лопатина