Synthesis and Evaluation of Antibacterial Activity of Cyclopropylphosphonates

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Abstract

Phosphonyl-substituted cyclopropanes were obtained by the reaction of O,O-diethyl (1,2-dibromoethyl)phosphonate with CH-acids, in particular, acetylacetone, acetoacetic and malonic esters, ethyl ester and amide of cyanoacetic acid, and benzyl cyanide, in the presence of a base in acetonitrile at room temperature. Antibacterial activity of the starting phosphonate and its derivatives was studied.

About the authors

G. T. Gasparyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

Email: arpenikb@mail.ru
Yerevan, 0014 Armenia

A. S. Bichakhchyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

Email: arpenikb@mail.ru
Yerevan, 0014 Armenia

L. V. Derdzyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

Email: arpenikb@mail.ru
Yerevan, 0014 Armenia

T. T. Khachatryan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

Email: arpenikb@mail.ru
Yerevan, 0014 Armenia

L. R. Gasparyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

Email: arpenikb@mail.ru
Yerevan, 0014 Armenia

Z. Z. Mardiyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia; SPC «Armbiotechnology» of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0056 Armenia

Email: arpenikb@mail.ru
Yerevan, 0014 Armenia; Yerevan, 0056 Armenia

R. E. Muradyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

Email: arpenikb@mail.ru
Yerevan, 0014 Armenia

H. H. Arakelyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia

Email: arpenikb@mail.ru
Yerevan, 0014 Armenia

A. S. Poghosyan

Scientific Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0014 Armenia; SPC «Armbiotechnology» of the National Academy of Sciences of the Republic of Armenia, Yerevan, 0056 Armenia

Author for correspondence.
Email: arpenikb@mail.ru
Yerevan, 0014 Armenia; Yerevan, 0056 Armenia

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