Nucleolus, ribosome biogenesis and tumor growth: literature review



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Abstract

The review examines aspects of the interrelationships of the morpho-functional activity of the nucleolus and ribosome biogenesis with the occurrence and progression of malignant neoplasms. To prepare this literature review, an electronic systematic search was conducted for review and research articles in the PubMed database devoted to the study of the nucleolar apparatus of cells in tumor growth. The information was searched in English for the following keywords: nucleolus, nuclear stress, ribosome biogenesis, cancer. The mechanisms of nucleolar stress and the molecular mechanisms leading to disruption of the nucleolar apparatus during tumor growth are highlighted. It has been shown that mutations and changes in the expression of suppressor proteins, oncogenes, and cell cycle regulators lead to impaired nucleolar function and accelerated ribosome biogenesis. An increase in the number and size of nucleoli is an important prognostic factor in malignant neoplasms. Disruption of the function of the nucleolar apparatus and changes in the structure of ribosomes is important in the pathogenesis of cancer development against the background of ribosomopathy and viral diseases. The study of the molecular mechanisms underlying the pathology of the nucleolus, biogenesis and pathology of ribosomes can contribute to the development of new targeted drugs for the treatment of cancer.

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About the authors

Igor P. Bobrov

Altai State Medical University, Barnaul

Email: ig.bobrov2010@yandex.ru
ORCID iD: 0000-0001-9097-6733
SPIN-code: 2375-1427

MD, Dr. Sci (Medicine), Professor of the Department of Forensic Medicine named after Professor V.N. Kryukov and Pathological Anatomy with a course of additional professional education

Russian Federation, Barnaul, Russia

Alexandr F. Lazarev

Altai State Medical University, Barnaul

Email: lazarev@akzs.ru
ORCID iD: 0000-0003-1080-5294
SPIN-code: 1161-8387

MD, Dr. Sci. (Medicine), Professor of the Department of Oncology and Radiation Therapy with a course of additional professional education

Russian Federation, Barnaul, Russia

Nikolay A. Korsikov

Altai State Medical University, Barnaul

Email: nikkor94knaagmu@yandex.ru
ORCID iD: 0000-0002-0094-4656
SPIN-code: 2534-3641

Assistant of the Department of Forensic Medicine named after Professor V.N. Kryukov and Pathological Anatomy with a course of additional professional education

Russian Federation, Barnaul, Russia

Andrey Yu. Dolgatov

Altai State Medical University, Barnaul

Email: adolgatov@yandex.ru
ORCID iD: 0000-0002-7677-4622
SPIN-code: 2804-0011

MD, Cand. Sci. (Medicine), Assistant Professor of the Department of Forensic Medicine named after Professor V.N. Kryukov and Pathological Anatomy with a course of additional professional education

Russian Federation, Barnaul, Russia

Alexander V. Lepilov

Altai State Medical University, Barnaul

Email: lepilov@list.ru
ORCID iD: 0000-0003-2477-4687
SPIN-code: 7516-0963

MD, Dr. Sci. (Medicine), Professor, Head of the Department of Forensic Medicine named after Professor V.N. Kryukov and Pathological Anatomy with a course of additional professional education

Russian Federation, Barnaul, Russia

Elena S. Dolgatova

Altai State Medical University, Barnaul

Email: adolgatov@yandex.ru
ORCID iD: 0000-0002-6678-4472
SPIN-code: 5801-0114

Assistant of the Department of Forensic Medicine named after Professor V.N. Kryukov and Pathological Anatomy with a course of additional professional education

Russian Federation, Barnaul, Russia

Anna A. Pimenova

Altai State Medical University, Barnaul

Email: k-sudmed@asmu.ru
ORCID iD: 0009-0002-9382-2857
SPIN-code: 7516-0976

Postgraduate student of the Department of Forensic Medicine named after Professor V.N. Kryukov and Pathological Anatomy with a course of additional professional education

Russian Federation, Barnaul, Russia

Elena L. Lushnikova

Institute of Molecular Pathology and Pathomorphology of the Federal Research Center for Fundamental and Translational Medicine, Novosibirsk

Email: pathol@inbox.ru
ORCID iD: 0000-0002-2614-8690
SPIN-code: 3310-1175

MD, Dr. Sci. (Medicine), Professor, Director of the Institute of Molecular Pathology and Pathomorphology. Academician of the Russian Academy of Natural Sciences

Russian Federation, Novosibirsk, Russia

Maxim A. Bakarev

Institute of Molecular Pathology and Pathomorphology of the Federal Research Center for Fundamental and Translational Medicine, Novosibirsk

Author for correspondence.
Email: pathol@inbox.ru
ORCID iD: 0000-0002-9614-592X
SPIN-code: 3630-9977

MD, Dr. Sci. (Medicine), Professor, Head of the laboratory – chief researcher

Russian Federation, Novosibirsk, Russia

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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