Russian Journal of OncologyRussian Journal of Oncology1028-99842412-9119Eco-Vector3978710.17816/onco39787Neoad\"yuvantnaya prolongirovannaya khimioluchevaya terapiya s posleduyushchey gastrektomiey D2 u bol'nykh mestno-rasprostranennym rakom zheludkaSkoropadV Yuskoropad@mrrc.obninsk.ruBerdovB A-TitovaL N-MardynskiyYu S-EvdokimovL V-Silant'evaN K-AgababyanT A-NeborakYu T-AgafonovV V-15082010154101522072020Copyright © 2010, Eco-Vector2010The authors report the preliminary results of Phase II clinical trial of the new method of multimodal treatment for locally advanced gastric cancer - preoperative neoadjuvant chemoradiotherapy. The procedure for the latter is well tolerated by patients and causes moderate, treatable reactions. Preoperative exposure does not complicate surgical intervention. There were no postoperative complications or deaths. The clinical and morphological evaluation of tumor responses showed that most patients had significant regression of both a primary tumor and regional metastases. Long-term neoadjuvant chemoradiotherapy followed by D2 gastrectomy in patients with locally advanced gastric cancer is a warranted and promising treatment calling for further clinical studies.locally advanced gastric cancerneoadjuvant chemoradiotherapyD2 gastrectomycombination treatmentместно-распространенный рак желудканеоадъювантная химиолучевая терапиягастрэктомия D2комбинированное лечение[Злокачественные новообразования в России в 2007 г. (заболеваемость и смертность) / Под ред. В. И. Чиссова и др. - М., 2009.][Лавникова Г. А. // Вестн. АМН СССР. - 1976. - № 6. - С. 13-19.][Онкология. Национальное руководство / Под ред. В. И. Чиссова, М. И. Давыдова. - М., 2008.][AJCC Cancer Staging Handbook. TNM Classification of Malignant Tumors. - 6-th Ed. - 2002.][Ajani J. A., Winter K., Okawara G. S. et al. // J. Clin. Oncol. - 2006. - Vol. 24. - P. 3953-3958.][Chirieac L. R., Swisher S. G., Ajani J. A. et al. // Cancer. - 2005. - Vol. 103. - P. 1347-1355.][Cunningham D., Allum W. H., Stenning S. P. et al. // N. Engl. J. Med. - 2006. - Vol. 355. - P. 11-20.][Gaca J. G., Petersen R. P., Peterson B. L. // Ann. Surg. Oncol. - 2006. - Vol. 13. - P. 340-346.][Guidelines for the Clinical and Pathological Studies on Carcinoma of the Esophagus. - Tokyo, 1999.][Japanese Classification of Gastric Carcinoma // Gastric Cancer. - 1998. - Vol. 1. - P. 10-24.][Macdonald J. S., Smalley S. R., Benedetti J. // N. Engl. J. Med. - 2001. - Vol. 345. - P. 725-730.][Mandard A. M., Dalibard F., Mandard J. C. // Cancer. - 1994. - Vol. 73. - P. 2680-2686.][Roth A. D., Allal A. S., Brundler M.-A. et al. // Ann. Oncol. - 2003. - Vol. 14. - P. 110-115.][Samel S., Hofheinz R., Hundt A. et al. // Onkologie. - 2001. - Bd 24. - S. 278-282.][Stahl M., Walz M. K., Stuschke M. et al. // J. Clin. Oncol. - 2009. - Vol. 27. - P. 851-856.][Wydmanski J., Suwinski R., Poltorak S. et al. // Radiother. Oncol. - 2007. - Vol. 82. - P. 132-136.]