Russian Journal of OncologyRussian Journal of Oncology1028-99842412-9119Eco-Vector3989110.17816/onco39891Clinical aspects of the molecular genetic profile of uterine carcinosarcomaLevitskayaN V-PozharisskiyK M-VostryukhinaO A-AlekseevaL N-NemtsovaM V-MatrosovaI V-PoddubnayaI V-LevitskayaN V-PozharisskyK M-VostryukhinaO A-AlekseyevaL N-NemtsovaM V-MatrosovaI V-PoddubnayaI V-15102011165252922072020Copyright © 2011, Eco-Vector2011The paper gives the results of a molecular genetic study of tumor tissues from 13 patients with uterine carcinosarcoma. Having determined damages to genes (K-RAS exon 1, TP53 exons 5-9, PTEN exons 5 and 8) in the components of carcinosarcoma, the authors assessed each of the study parameters as a potentially clinical prognostic criterion. Whether aberrant TP53 and PTEN and tumor clonality could be used as clinical markers was confirmed.PTENuterine carcinosarcomaclonalityTP53PTENкарциносаркома маткиклональность TP53[Имянитов Е. Н., Хансон К. П. // Молекулярная онкология: клинические аспекты. - СПб., 2007. - С. 148.][Немцова М. В., Башкатов С. В., Корякин О. Б. и др. // Системы генетических и эпигенетических маркеров в диагностике онкологических заболеваний. - М., 2009. - С. 188- 215.][Тимофеев А. В., Алексеева Л. Н., Мацко Д. Е. и др. // Вопр. онкол. - 2008. - Т. 54, № 1. - С. 47-52.][Goelz S., Hamilton S., Vogelstein B. // Biochem. Biophys. Res. Commun. - 1985. - Vol. 130. - P. 118-126.][Isobe M., Emmanual B. S., Givol D. // Nature. - 1986. - Vol. 320. - P. 84-85.][Janiec-Jankowska A., Konopka B., Goluda C. et al. // Int. J. Gynecol. Cancer. - 2010. - Vol. 20, N 2. - P. 196-202.][Jopp H., Krone H. // Arch. Gynaekol. - 1962. - Vol. 197, N 4. - P. 387-397.][Kounelis S., Jones M. W., Papadaki H. et al. // Hum. Pathol. - 1998. - Vol. 29, N 1. - P. 82-87.][McCluggage W. G. // J. Clin. Pathol. - 2002. - Vol. 55. - P. 321-325.][Sreenan J. J., Hart W. R. // Am. J. Surg. Pathol. - 1995. - Vol. 19, N 6. - P. 666-674.][Tavassoli A., Devilee P. Pathology and genetics of tumours of the breast and femal genital organs. - Lyon, 2003. - P. 245- 249.][Wada H., Enomoto T., Fujita M. et al. // Cancer Res. - 1997. - Vol. 57. - P. 5379-5385.][Zhu Y., Hoell P., Ahlmeyer B. et al. // Apoptosis. - 2006. - Vol. 11. - P. 197-207.]