Russian Journal of OncologyRussian Journal of Oncology1028-99842412-9119Eco-Vector3998410.17816/onco39984Research ArticleCHANGES IN HEMOSTATIC SYSTEM OF CERTAIN MALIGNANT TUMORSShilovaA. N-LazarevA. F-KarmadonovaN. A-KudrjavtsevA. S-AnikeevaO. Yu-Academician E.N. Meshalkin Novosibirsk Research Institute of Blood Circulation PathologyAltay branch of N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences1508201318491122072020Copyright © 2013, Eco-Vector2013The parameters of coagulation hemostasis in 37 patients with gastric cancer, 65 patients with colon cancer, 17 patients with prostate cancer and in 8 patients with lung cancer were analyzed. The aggregation of platelets in 119 patients with tumors of the breast, 17 — stomach cancer, 11 — colon cancer, 17 — prostate cancer and 8 — lung cancer also were analyzed. It was found that cancer patients have hyperthrombinemia, hyperfibrinogenemia, violation of the protein C system, reduction of the antithrombin III concentration, increase of induced platelet aggregation, which contributes to the formation of the thrombophilic status in cancer patients, is significant in the progression of the tumor and its metastasis. The use of anticoagulants and antiplatelets by these patients can not only lead to a decrease in the risk of thrombotic complications, but also to improve the survival of cancer patients.cancer patientshemostasisthromboembolic complicationsthrombophilic statusонкологические больныегемостазтромбоэмболические осложнениятромбофилический статус[Bloom J.W., Vanderschoot J.P.M., Oostindiër M.J., Osanto S., van der Meer F.J., Rosendaal F.R. Incidence of venous thromboembolism in a large cohort of 66329 cancer patients results of a record linkage study. J. Thromb. Haemost. 2006; 4: 529—35.][Bura A., Cailleux N., Bienvenu B., Léger P., Bissery A., Boccalon H. et al. Incidence and prognosis of cancer associated with bilateral venous thrombosis: a prospective study of 103 patients. J. Thromb. Haemost. 2004; 2: 441—4.][Prandoni P., Falanga A., Piccioli A. Cancer and venous thromboembolism. Lancet Oncol. 2005; 6: 401—10.][White R.H., Chew H.K., Zhou H., Parikh-Patel A., Harris D., Harvey D., Wun T. Incidence of venous thromboembolism in the year before the diagnosis of cancer in 528693 adults. Arch. Intern. Med. 2005; 165: 1782—7.][Ходоренко С.А., Шилова А.Н., Баркаган З.С., Лазарев А.Ф., Россоха А.В., Назаров А.В. и др. Венозные тромбоэмболии у онкологических больных в послеоперационном периоде. Сибирский онкологический журнал. 2008; 4 (28): 59—61.][Шилова А.Н., Баркаган З.С. Современные данные о частоте и патогенезе онкотромбозов. Тромбоз, гемостаз и реология. 2006; 1: 6—15.][Hettiarachchi R.J., Smorenburg S.M., Ginsberg J., Levine M., Prins M.H., Büller H.R. Do heparins do more than just treat thrombosis? The influence of heparins on cancer spread. Thromb. Haemost. 1999; 82: 947—52.][Amirkhosravi A., Francis J., Mousa S. Anti-metastatic effect of low molecular weight heparin Tinzaparin and Tissue Factor Pathway Inhibitor. Haemostasis. 2001; 31 (Suppl. 1): 87.][Mousa S. Anti-angiogenic efficacy and mechanism of the low molecular weight heparin, Tinzaparin and Tissue Factor Pathway Inhibitor: Anticancer benefits. Haemostasis. 2001; 31 (Suppl. 1): 86—7.][Баркаган З.С., Шилова А.Н., Воробьев П.А., Лазарев А.Ф., Котовщикова Е.Ф., Ходоренко С.А. и др. Клинико-экономический анализ применения различных антикоагулянтов для профилактики тромбоэмболических осложнений у больных раком желудка и толстой кишки. Вестник РОНЦ им. Н.Н.Блохина РАМН. 2008; 19 (3): 26—8. Для корреспонденции: Шилова Анна Николаевна - д-р мед. наук, зав. лаб. клинико-биохимических исследований; 630055, г. Новосибирск, ул. Речкуновская, 15, e-mail: shilovaanna77@mail.ru][Лазарев А.Ф., Шилова А.Н., Ходоренко С.А., Момот А.П. Нарушения гемостаза при онкологических заболеваниях. Барнаул: АЗБУКА; 2012.][Шилова А.Н. Методы медикаментозной профилактики и лечения тромбозов у онкологических больных, их влияние на рост и метастазирование опухолей, на выживаемость больных. Сибирский онкологический журнал. 2012; 2: 79—83.]