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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский онкологический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1028-9984</issn><issn publication-format="electronic">2412-9119</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">39997</article-id><article-id pub-id-type="doi">10.17816/onco39997</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">CLINICAL SEMIOTICS AND SURGICAL PREOPERATIVE DIAGNOSIS OF STAGE-I BREAST CANCER</article-title><trans-title-group xml:lang="ru"><trans-title>КЛИНИЧЕСКАЯ СЕМИОТИКА И ПРЕДОПЕРАЦИОННАЯ ХИРУРГИЧЕСКАЯ ДИАГНОСТИКА РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ I СТАДИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kolyadina</surname><given-names>I. V</given-names></name><name xml:lang="ru"><surname>Колядина</surname><given-names>Ирина Владимировна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, ассистент каф. онкологии</p></bio><email>irinakolyadina@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Komov</surname><given-names>D. V</given-names></name><name xml:lang="ru"><surname>Комов</surname><given-names>Д. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Poddubnaya</surname><given-names>I. V</given-names></name><name xml:lang="ru"><surname>Поддубная</surname><given-names>И. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Danzanova</surname><given-names>T. Yu</given-names></name><name xml:lang="ru"><surname>Данзанова</surname><given-names>Т. Ю</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kostyakova</surname><given-names>L. A</given-names></name><name xml:lang="ru"><surname>Костикова</surname><given-names>Л. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sinyukova</surname><given-names>G. T</given-names></name><name xml:lang="ru"><surname>Синюкова</surname><given-names>Г. Т</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Banov</surname><given-names>S. M</given-names></name><name xml:lang="ru"><surname>Банов</surname><given-names>С. М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Medical Academy of Postgraduate Education</institution></aff><aff><institution xml:lang="ru">ГБОУ ДПО «Российская медицинская академия последипломного образования»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.N. Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» РАМН</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Clinic of Russian Medical Academy of Postgraduate Education</institution></aff><aff><institution xml:lang="ru">Клиника ГБОУ ДПО «Российская медицинская академия последипломного образования»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2013</year></pub-date><volume>18</volume><issue>4</issue><issue-title xml:lang="en">NO4 (2013)</issue-title><issue-title xml:lang="ru">№4 (2013)</issue-title><fpage>17</fpage><lpage>20</lpage><history><date date-type="received" iso-8601-date="2020-07-22"><day>22</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, ООО "Эко-Вектор"</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjonco.com/1028-9984/article/view/39997">https://rjonco.com/1028-9984/article/view/39997</self-uri><abstract xml:lang="en"><p>Screening tumors of breast are detected by instrumental methods of diagnosis, such as mammography (MG), ultrasonography (USG) and magnetic resonance imaging (MRI) only; typically have a size to 2.0 cm (T1) and need support (MG or USG control) at biopsy for morphological study. In the present study the clinical symptoms were analyzed using a large clinical data (1,347 patients with stage-I breast cancer), the rate of screening tumors and the possibility of pre-surgical biopsy of these tumors. The proportion of screening cancer, identified by instrumental methods of diagnosis was only 12.8%, which means the insufficient level of screening programs for all age groups women. Screening methods had the maximum diagnostic value in microcarcinomas (tumors less than 5 mm) which had no clinical symptoms and almost non-palpable. Young patients (&lt;40 years) found breast cancer themselves and went to oncologist (more than 90% of cases; patients 50 years older - in 78% cases, p &lt;0,05). Surgical biopsy with USG or MG control has improved the effectiveness of a biopsy from 74.4% (without instrumental control) to 93%; core-biopsy of tumors has helped to determinate of morphological diagnosis more exactly and plan treatment algorithm in these patients.</p></abstract><trans-abstract xml:lang="ru"><p>Скрининговые опухоли молочной железы выявляются только при инструментальных методах диагностики, таких как маммография (ММГ), ультразвуковое исследование (УЗИ) и магнитно-резонансная томография (МРТ), обычно имеют размеры до 2 см (Т1) и требуют поддержки (контроль ММГ или УЗИ) при заборе материала для морфологического исследования. В представленном исследовании была проанализирована клиническая симтоматика рака молочной железы I стадии на большом клиническом материале (1347 пациенток), определена доля скринингового рака и возможности хирургической предоперационной диагностики заболевания. Доля скринингового рака, выявленного при инструментальных методах диагностики, составила всего 12,8%, что говорит о недостаточном уровне скрининговых программ у женщин всех возрастных групп. Максимальную диагностическую ценность скрининговые инструментальные методы диагностики имеют при микрокарциномах (опухоли менее 5 мм), которые не имеют клинических проявлений и практически не пальпируются. Пациентки моложе 40 лет гораздо чаще самостоятельно обнаруживали опухоль в молочной железе и обращались к онкологу (более чем 90% случаев), в то время как пациентки старше 50 лет опухоль выявляли не чаще, чем в 78% случаев (р &lt; 0,05). Предоперационная хирургическая верификация диагноза под инструментальным контролем (УЗИ или ММГ) позволила повысить результативность биопсии с 74,4% (без инструментального контроля) до 93%, а использование аппаратной core-биопсии позволила максимально точно установить морфологический диагноз и спланировать лечебный алгоритм.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Screening breast cancer</kwd><kwd>clinical symptoms of breast cancer I-stage</kwd><kwd>fine-needle biopsy (FNAB) and corebiopsy with USG and MG control</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>скрининговый рак молочной железы</kwd><kwd>клинические проявления при раке молочной железы I стадии</kwd><kwd>тонкоигольная биопсия</kwd><kwd>core-биопсия под контролем УЗИ и маммографии</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Giger M.L., Karssemeijer N., Schnabel J.A. 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