Russian Journal of OncologyRussian Journal of Oncology1028-99842412-9119Eco-Vector4000410.17816/onco40004Research ArticleMorphofunctional characteristics of fibroblasts in peritumorous zone of renal cell carcinoma in different degrees of malignancyCherdantsevaT. Mdrakon@agmu.ruBobrovI. P-KlimachevV. V-BryuhanovV. M-LazarevA. F-AvdalyanA. M-DolgatovA. Yu-SamartsevN. S-15122013186121622072020Copyright © 2013, Eco-Vector2013Morphological and functional activity of fibroblasts in peritumorous zone (PZ) in renal cancer has been studied in 33 patients, using microspectrophotometrical, histological and histochemical methods. Activity of fibroblasts morphofunctional PZ depended on tumors ’ malignancy degree and was highest in most malignant tumors. Morphofunctional fibroblasts ’ activity correlated with width, degree of severity of sclerosis and neoangiogenesis of kidney cancer PZ.cancerkidney peritumorous areasfibroblastsрак почкиперитуморозная зонаклетки фибробластического ряда[Cirri P., Chiarugi P. Cancer associated fibroblasts: the dark side of the coin. Am. J. Cancer Res. 2011; 1: 482—97.][Kalluri R., Zeisberg M. Fibroblasts in cancer. Nature Rev. Cancer. 2006; 6: 392—401.][Karagiannis G.S., Poutahidis T., Erdman S.E., Kirsch R., Riddell R.H., Diamandis E.P. Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue. Mol. Cancer Res. 2012; 10: 1403—18.][Bhowmick N.A., Neilson E.G., Moses H.L. Stromal fibroblasts in cancer initiation and progression. Nature. 2004; 432: 332—7.][Vered M., Dayan D., Yahalom R., Dobriyan A., Barshack I., Bello I.O., Kantola S., Salo T. Cancer-associated fibroblasts and epithelial-mesenchymal transition in metastatic oral tongue squamous cell carcinoma. Int. J. Cancer. 2010; 127: 1356—62.][Räsänen K, Vaheri A. Activation of fibroblasts in cancer stroma. Exp. Cell Res. 2010; 316: 2713—22.][De Wever O., Mareel M. Role of tissue stroma in cancer cell invasion. J. Pathol. 2003; 200: 429—47.][Strutz F., Zeisberg M., Hemmerlein B., Sattler B., Hummel K., Becker V., Müller G.A. Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation. Kidney Int. 2000; 57: 1521—38.][Nakao M., Ishii G., Nagai K., Kawase A., Kenmotsu H., Kon-No H., Hishida T., Nishimura M., Yoshida J., Ochiai A. Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma. Cancer. 2009; 115: 2732—43.][Hasebe T., Iwasaki M., Akashi-Tanaka S., Hojo T., Shibata T., Sasajima Y., Kinoshita T., Tsuda H. p53 expression in tumor-stromal fibroblasts forming and not forming fibrotic foci in invasive ductal carcinoma of the breast. Mod. Pathol. 2010; 23: 662—72.][Zhi K., Shen X., Zhang H., Bi J. Cancer-associated fibroblasts are positively correlated with metastatic potential of human gastric cancers. J. Exp. Clin. Cancer Res. 2010; 29: 66.][Togo S., Polanska U.M., Horimoto Y., Orimo A. Carcinoma-ssociated fibroblasts are a promising therapeutic target. Cancers. 2013; 5: 149—69.][Martinez-Zubiaurre I., Fenton C.G., Taman H., Pettersen I., Hellevik T., Paulssen R.H. Tumorigenic responses of cancer-associated stromal fibroblasts after ablative radiotherapy: a transcriptome-profiling study. J. Cancer Ther. 2013; 4: 208—50.][Бобров И.П., Авдалян А.М., Климачев В.В., Лазарев А.Ф., Гервальд В.Я., Долгатов А.Ю. и др. Модификация гистохимического метода выявления ядрышковых организаторов на гистологических срезах. Архив патологии. 2010; 3: 35—7.][Челидзе П.В., Зацепина О.В. Морфофункциональная классификация ядрышек. Успехи современной биологии. 1988; 105: 252—8.]