Russian Journal of OncologyRussian Journal of Oncology1028-99842412-9119Eco-Vector4015310.17816/onco40153Research ArticleMalignancies in children in Russia: trends and highlightsMen'T. KhPediatric Oncology and Hematology Research Institute-RykovMaksim Yu.MD, PhDwordex2006@rambler.ruPolyakovV. GPediatric Oncology and Hematology Research Institute-N.N. Blokchin Russian Cancer Research CenterRussian Medical Academy of Postgraduate Education15042015202434722072020Copyright © 2015, Eco-Vector2015Objective - to determine current rates of childhood cancer incidence and mortality at a national level for Russia and to evaluate recent trends. Material and methods. Using the Annual reports of Ministry of health and Federal State Statistics Service we calculated childhood cancer incidence and mortality rates for the 5-year period 2008-2012 and trends between 1989 and 2012 by sex, age and site. Rates were directly age-standardised to the 2000 World Standard Population, and linear regression was used to determine the magnitude and significance of trends. Results. The age-adjusted incidence rate in children aged 0-17 years was 125 per 1,000, 000 individuals per year for 2008-2012. The highest age-specific incidence (159 per 1,000,000 children/year) was observed in early childhood (0-4 years). Between 1989 and 2012, a significant increase in the cancer incidence was observed in children aged 0-14 years: average annual percent change was 1,6% [95%CI 1,5%; 1,7%]. The greatest increase for this period was observedfor soft tissue sarcomas (3,7% [2,6; 4,9]), hepatic tumors (3,6% [2,6; 4,6]), thyroid carcinomas (3,7% [3,2; 4,2]), CNS neoplasms (2,9% [2,6; 3,1]), renal tumors (2,1% [1,7; 2,5]) and leukaemias (1,9% [1,7; 2,1]). The decrease of incidence was observed for Hodgkin (- 1,6% [-2,1; -1,2]) and non-Hodgkin (- 1.4% [-1,8; -1,0]) lymphomas. Childhood cancer mortality for 2008-2012 was 40 cases per 1000,000 children/year. The highest age-specific mortality rate (52,3 per 1,000,000) was observed in infants. The significant decrease of mortality were found from 1989 (70 per million) to 2012 (37per million). The greatest average annual decrease for this period was observedfor leukaemias (-3,8% [-4,0; -3,5]) and lymphomas (-6,8% [-7,3; -6,4]). The significant decrease of mortality in 19992012 was foundfor malignant bone tumors( -5,9% [-7,4; -4,3]), renal tumors (-2,9% [-4,7; -1,1]) and CNS neoplasms (-1,1% [-1,9; -0,3]) with the only exeption for soft tissue sarcomas (average annual increase was 3,2% [1,8; 4,7]). Conclusion. Significant temporal trends of childhood cancer incidence and mortality in Russia were found during the study period. Although rates of cancer mortality are generally decreasing in Russia there are still very high levels for common childhood cancer types.cancerchildren and adolescentsepidemiologyRussiaзлокачественные новообразованиядети и подросткиэпидемиологияРоссия[Steliarova-Foucher E., Stiller C., Lacour B. et al. International Classification of Childhood Cancers, 3-d ed. Cancer. 2005; 103: 1457-67.][Campo E., Swerdlow S.H., Harris N.L. et al. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011; 117 (19): 5019-32.][SEER Cancer Statistics Review 1975-2010. /http://seer.cancer.gov/][Ellison L.F., De P., Mery L.S., Grundy P.E. Canadian cancer statistics at a Glance: Cancer in children. Can. Med. Assoc. J. 2009; 180 (4): 422-4.][Childhood Cancer Incidence in Australia, 1983-2006. / http://www.cancerqld.org.au/.][German Childhood Cancer Registry. Annual Report. 2012. http://www.kinderkrebsregister.de/dkkr-gb/latest-publications][Engholm G., Ferlay J., Christensen N., Johannesen T.B., Khan S., Kitlum J.E. et al. NORDCAN: Cancer Incidence, Mortality, Prevalence and Prediction in the Nordic Countries. Version 6.0. 2013; Association of the Nordic Cancer Registries. Danish Cancer Society, http://www.ancr.nu][Gatta G., Botta L., Rossi S., Aareleid T., Bielska-Lasota M., Clavel J. et al. Childhood cancer survival in Europe 1999-2007: results of EUROCARE-5 - a population-based study. Lancet Oncol. 2014; 15 (1): 35-47.][Мерабишвили В.М. Выживаемость онкологических больных. СПб. 2011; вып. 2, ч. 1.][Kachanov D.Y, Dobrenkov K.V., Abdullaev R.T., Shamanskaya T.V., Varfolomeeva S.R. Incidence and survival of pediatric soft tissue sarcoma in Moscow region, Russia. Sarcoma. 2012; doi:10.1155/2012/350806.][Федякова Ю.С., Мень Т.Х., Поляков В.Г. Нейробластома у детей в городе Москве: популяционное исследование. Детская онкология. 2008; 2: 50-3.][Statistical Methods in Cancer Research, Vol. IV: Descriptive Epidemiology. IARC Scientific Publications № 128. 1994.]