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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский онкологический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1028-9984</issn><issn publication-format="electronic">2412-9119</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">40206</article-id><article-id pub-id-type="doi">10.17816/onco40206</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Long-term trastuzumab biotherapy of a breast cancer patient</article-title><trans-title-group xml:lang="ru"><trans-title>Длительная биотерапия трастузумабом больной раком молочной железы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Volodina</surname><given-names>L. N</given-names></name><name xml:lang="ru"><surname>Володина</surname><given-names>Л. Н</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kulikov</surname><given-names>E. P</given-names></name><name xml:lang="ru"><surname>Куликов</surname><given-names>Е. П</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Grigoryev</surname><given-names>A. V</given-names></name><name xml:lang="ru"><surname>Григорьев</surname><given-names>А. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bublokova</surname><given-names>M. P</given-names></name><name xml:lang="ru"><surname>Бубликова</surname><given-names>М. П</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zhuravleva</surname><given-names>O. P</given-names></name><name xml:lang="ru"><surname>Журавлева</surname><given-names>О. П</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Chernova</surname><given-names>V. V</given-names></name><name xml:lang="ru"><surname>Чернова</surname><given-names>В. В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kolobaeva</surname><given-names>R. E</given-names></name><name xml:lang="ru"><surname>Колобаева</surname><given-names>Р. Е</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sashina</surname><given-names>E. L</given-names></name><name xml:lang="ru"><surname>Сашина</surname><given-names>Е. Л</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sonina</surname><given-names>L. A</given-names></name><name xml:lang="ru"><surname>Сонина</surname><given-names>Л. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mertsalov</surname><given-names>Sergey A.</given-names></name><name xml:lang="ru"><surname>Мерцалов</surname><given-names>Сергей Александрович</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD</p></bio><bio xml:lang="ru"><p>канд. мед. наук, ассистент каф. онкологии с курсом лучевой диагностики</p></bio><email>mrst16rzn@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mirchetich</surname><given-names>A. S</given-names></name><name xml:lang="ru"><surname>Мирчетич</surname><given-names>А. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vinogradov</surname><given-names>I. Yu</given-names></name><name xml:lang="ru"><surname>Виноградов</surname><given-names>И. Ю</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kholchev</surname><given-names>M. Yu</given-names></name><name xml:lang="ru"><surname>Холчев</surname><given-names>М. Ю</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Ryazansky Regional Clinical Oncology Dispensary</institution></aff><aff><institution xml:lang="ru">ГБУ «Рязанский областной клинический онкологический диспансер»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.P. Pavlov Ryazansky State Medical University</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Рязанский государственный медицинский университет им. акад. И.П. Павлова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2015</year></pub-date><volume>20</volume><issue>5</issue><issue-title xml:lang="en">VOL 20, NO5 (2015)</issue-title><issue-title xml:lang="ru">ТОМ 20, №5 (2015)</issue-title><fpage>31</fpage><lpage>33</lpage><history><date date-type="received" iso-8601-date="2020-07-22"><day>22</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ООО "Эко-Вектор"</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjonco.com/1028-9984/article/view/40206">https://rjonco.com/1028-9984/article/view/40206</self-uri><abstract xml:lang="en"><p>The paper describes a clinical case of long-term Trastuzumab biotherapy of a patient with HER2-positive breast cancer. The patient with morphology confirmed HER2+ breast cancer has received Trastuzumab therapy over 9 years. CT data proved complete resorption of metastases in the lungs. No adverse events, which could limit trastuzumab treatment, were noted. The clinical case illustrates effective long-term Trastuzumab therapy of a patient with metastatic HER2+ breast cancer.</p></abstract><trans-abstract xml:lang="ru"><p>В статье представлено описание клинического случая длительной многолетней биотерапии препаратом трастузумабом у больной с HER2-положительным раком молочной железы. Пациентке с морфологически подтвержденным метастатическим HER2-положительным раком молочной железы в течение 9 лет проводится терапия трастузумабом. Отмечается полная резорбция метастазов в легких, подтвержденная компьютерной томографией. Нежелательных явлений, ограничивающих использование трастузумаба, не отмечается. Клинический случай иллюстрирует возможности эффективного длительного применения трастузумаба у пациентки с метастатическим HER2-положительным раком молочной железы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>long-term Trastuzumab therapy</kwd><kwd>metastatic breast cancer</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>длительная терапия трастузумабом</kwd><kwd>метастатический рак молочной железы</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Семиглазов В.Ф., Семиглазов В.В., Палтуев Р.М. Биологическое обоснование планирования лечения рака молочной железы. Врач. 2012; 11: 2-4.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Белохвостова А.С., Смирнова И.А., Енилеева А.А. Таргетная терапия в лечении HER2-позитивного рака молочной железы. Сибирский онкологический журнал. 2013; 2 (56): 84-8.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Minckwitz G. 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