Russian Journal of OncologyRussian Journal of OncologyРоссийский онкологический журнал1028-99842412-9119Eco-Vector4028210.18821/1028-9984-2016-21-4-172-174ArticlesСтатьиResearch ArticleFemale reproductive system tumors with Merkel cell phenotypeОпухоли женской репродуктивной системы с фенотипом клеток МеркеляNikogosyanSeda O.НикогосянСеда Овиковна

MD, PhD, DSc, Leading researcher of the Gynecological Department of the Research Institute of Clinical Oncology

д-р мед. наук, ведущий научный сотрудник гинекологического отделения НИИ клинической онкологии

zagamedik@mail.ruTagibovaT. ShТагибоваТ. ШKuznetsovV. VКузнецовВ. ВAnurovaO. AАнуроваО. АN.N. Blokhin Russian Cancer Research CenterФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава России15082016214VOL 21, NO4 (2016)ТОМ 21, №4 (2016)17217422072020Copyright ©; 2016, Eco-VectorCopyright ©; 2016, ООО "Эко-Вектор"2016Eco-VectorООО "Эко-Вектор"https://rjonco.com/1028-9984/article/view/40282

Diagnostics and treatment of female reproductive system tumors with Merkel cell phenotype, rare aggressive tumors with dismal prognosis, is under consideration in this article. Only 20 cases of Merkel cell vulvar carcinoma and 1 case of Merkel cell vagina cancer were described in the literature. Diagnostics must include immunohistochemical analysis, as expression of cytokeratine 20 proves to be the most typical factor. Polyomavirus infection is believed to be associated with the disease pathogenesis. No treatment standards were accepted due to the rarity of the disease. Considering the data on tumor radiosensitivity, the treatment must include radio- or chemoradiotherapy.

Статья посвящена вопросам диагностики и лечения рака из клеток Меркеля, крайне редкой опухоли, характеризующейся агрессивым течением и неблагоприятным прогнозом. В литературе описано около 20 случаев рака вульвы с фенотипом клеток Меркеля и 1 случай рака влагалища аналогичного строения. Диагностика заболевания должна включать проведение иммуногистохимического исследования, характерным является экспрессия цитокератина 20. Предполагается, что патогенез заболевания связан с носительством полиомавируса. В связи с редкостью заболевания отсутствуют единые стандарты лечения. Учитывая данные о радиочувствительности опухоли, лечение должно включать проведение лучевой или химиолучевой терапии.

Merkel cell carcinomapolyomavirusMerkel cell vulvar carcinomaMerkell cell vagina carcinomaрак из клеток Меркеляполиомавирусрак вульвы с фенотипом клеток Меркелярак влагалища с фенотипом клеток МеркеляMerkel F. Tastzellen und Tastkörperchen bei den Hausthieren und beim Menschen. Arch. mikroskop. Anat. 1875; 11: 636-52.Bonnet R. Studien uber die Innervation der Haarbalge der Hausthiere. Morphol. Jahrb. 1878; 4: 329-98.Halata Z., Grim M., Bauman K.I. Friedrich Sigmund Merkel and his «Merkel cell», morphology, development, and physiology: review and new results. Anat. Rec. Part A: Discov. Mol., Cell., Evol. Biol. 2003; 271: 225-39.Toker C. Trabecular carcinoma of the skin. Arch. Dermatol. 1972; 105: 107-10.Tang C.K., Toker C. Trabecular carcinoma of the skin. An ultrastructural study. Cancer. 1978; 42: 2311-21.De Wolf-Peeters C., Marien K., Mums J., Desmet V. A cutaneous APUDoma or Merkel cell tumor? A morphologically recognizable tumor with a biological and histological malignant aspect in contrast with its clinical behavior. Cancer. 1980; 46: 1810-6.Paik J.Y., Hall G., Clarkson A. et al. Immunohistochemistry for Merkel cell polyomavirus is highly specific but not sensitive for the diagnosis of Merkel cell carcinoma in the Australian population. Hum. Pathol. 2011; 42: 1385-90.Jaeger T., Ring J., Andres C. Histological, immunohistological, and clinical features of merkel cell carcinoma in correlation to merkel cell polyomavirus status. J. Skin Cancer. 2012; Article ID 983421.Moll R., Löwe A., Laufer J., Franke W. Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am. J. Pathol. 1992; 140: 427.Feng H., Shuda M., Chang Y., Moore P.S. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008; 319: 1096-100.Zeng Q., Gomez B.P., Viscidi R.P. et al. Development of a DNA vaccine targeting Merkel cell polyomavirus. Vaccine. 2012; 30: 1322-9.Lemos B.D., Storer B.E., Iyer J.G. et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J. Am. Acad. Dermatol. 2010; 63: 751-61.Asioli S., Righi A., Volante M. et al. p63 expression as a new prognostic marker in Merkel cell carcinoma. Cancer. 2007; 110: 640-7.Allen P.J., Bowne W.B., Jaques D.P. et al. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J. Clin. Oncol. 2005; 23: 2300-9.Albores-Saavedra J., Batich K., Chable-Montero F. et al. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J. Cutan. Pathol. 2010; 37: 20-7.Coleman N.M., Smith-Zagone M.J., Tanyi J. et al. Primary neuroendocrine carcinoma of the vagina with Merkel cell carcinoma phenotype. Am. J. Surg. Pathol. 2006; 30: 405-10.Sheikh Z.A., Nair I., Vijaykumar D.K. et al. Neuroendocrine tumor of vulva: a case report and review of literature. J. Cancer Res. Ther. 2010; 6: 365-6.Copeland L.J., Cleary K., Sneige N., Edwards C.L. Neuroendocrine (Merkel cell) carcinoma of the vulva: a case report and review of the literature. Gynecol. Oncol. 1985; 22: 367-78.Mohit M., Mosallai A., Monabbati A., Mortazavi H. Merkel cell carcinoma of the vulva. Saudi Med. J. 2009; 30: 717-8.Jonska-Gmyrek J., Bobkiewicz P., Gmyrek L. et al. Merkel cell carcinoma of the vulva - case report and the literature review. Ginekol. Pol. 2013; 84: 385-9.Lawenda B.D., Arnold M.G., Tokarz V.A. et al. Analysis of radiation therapy for the control of Merkel cell carcinoma of the head and neck based on 36 cases and a literature review. Ear Nose Throat. J. 2008; 87: 634-43.Mortier L., Mirabel X., Fournier C. et al. Radiotherapy alone for primary Merkel cell carcinoma. Arch. Dermatol. 2003; 139: 1587-90.Agelli M., Clegg L.X. Becker J.C., Rollison D.E. The etiology and epidemiology of merkel cell carcinoma. Curr. Probl. Cancer. 2010; 34: 14-37.Poulsen M., Rischin D., Walpole E. et al. High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: a Trans-Tasman Radiation Oncology Group Study-TROG 96:07. J. Clin. Oncol. 2003; 21: 4371-6.Swann M.H., Yoon J. Merkel cell carcinoma. In: Seminars in Oncology. Elsevier; 2007: 51-6.Veness M.J. Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma): an overview on management. Australas. J. Dermatol. 2006; 47: 160-5.Viola G., Visca P., Bucher S. et al. Merkel cell carcinoma. Clin. Ter. 2005; 157: 553-9.