<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский онкологический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1028-9984</issn><issn publication-format="electronic">2412-9119</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">40316</article-id><article-id pub-id-type="doi">10.18821/1028-9984-2016-21-4-198-200</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Small cell carcinoma of the ovary of hypercalcemic type: a case report</article-title><trans-title-group xml:lang="ru"><trans-title>Мелкоклеточный рак яичников (гиперкальциемический тип). Клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ashrafyan</surname><given-names>L. A</given-names></name><name xml:lang="ru"><surname>Ашрафян</surname><given-names>Л. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Panshin</surname><given-names>G. A</given-names></name><name xml:lang="ru"><surname>Паньшин</surname><given-names>Г. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bychkov</surname><given-names>Yu. M</given-names></name><name xml:lang="ru"><surname>Бычков</surname><given-names>Ю. М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Babaeva</surname><given-names>N. A</given-names></name><name xml:lang="ru"><surname>Бабаева</surname><given-names>Н. А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Bolshakova</surname><given-names>Svetlana A.</given-names></name><name xml:lang="ru"><surname>Большакова</surname><given-names>Светлана Алексеевна</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD, Senior researcher of the Group of anticancer drug therapy of the research department of innovative technologies of radiotherapy and chemoradiation treatment of malignant neoplasms</p></bio><bio xml:lang="ru"><p>канд. мед. наук, старший научный сотрудник группы противоопухолевой лекарственной терапии научно-исследовательского отдела инновационных технологий радиотерапии и химиолучевого лечения злокачественных новообразований</p></bio><email>bychkovy@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Scientific Center of Roentgenoradiology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российский научный центр рентгенорадиологии»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2016</year></pub-date><volume>21</volume><issue>4</issue><issue-title xml:lang="en">VOL 21, NO4 (2016)</issue-title><issue-title xml:lang="ru">ТОМ 21, №4 (2016)</issue-title><fpage>198</fpage><lpage>200</lpage><history><date date-type="received" iso-8601-date="2020-07-22"><day>22</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО "Эко-Вектор"</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjonco.com/1028-9984/article/view/40316">https://rjonco.com/1028-9984/article/view/40316</self-uri><abstract xml:lang="en"><p>The small cell carcinoma of the ovary is a rare tumor with the very modest prognosis. It usually occurs in young women and in two-thirds of cases is associated with hypercalcemia. The treatment combines surgery, chemotherapy, and radiotherapy. Case Presentation. We report a case of small cell carcinoma of the ovary hypercalcemic type in a young Russian woman of 33 years in whom the first manifestations were abdominal pain syndrome. A laparotomy was performed by radical surgery. There were performed 4 courses of chemotherapy, and then conventionally radical operation was executed. Histologically, the diagnosis was confirmed. There was performed palliative chemotherapy, the patient’s death occurred within 10 months after making of the diagnosis. Conclusion. Hypercalcemic type of ovarian cancer is a rare, aggressive tumor with a poor prognosis.</p></abstract><trans-abstract xml:lang="ru"><p>Мелкоклеточный рак яичников (гиперкальциемический тип) относится к редким опухолям с очень плохим прогнозом. Обычно развивается у молодых женщин и в 2/3 случаев сопровождается развитием гиперкальциемии. Лечение может включать в себя хирургический этап, химиотерапию, лучевую терапию. Клинический случай. Мы предоставляем данные по развитию мелкоклеточного рака яичников гиперкальциемического типа у молодой пациентки из России 33 лет, у которой манифестация заболевания началась с появления болей в животе. Проведено 4 курса химиотерапии, далее выполнена условно-радикальная операция. При гистологическом исследовании диагноз был подтвержден. Проводилась паллиативная химиотерапия, смерть пациентки наступила через 10 мес после постановки диагноза. Заключение. Гиперкальциемический тип рака яичников является редкой, агрессивной опухолью с плохим прогнозом.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ovary</kwd><kwd>small cell carcinoma</kwd><kwd>hypercalcemic type</kwd><kwd>chemotherapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>яичники</kwd><kwd>мелкоклеточный рак</kwd><kwd>гиперкальциемический тип</kwd><kwd>химиотерапия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Tavassoli F.A., Devilee P., eds. World Health Organization Classification of Tumors. Pathology and Generics of Tumors of the Breast and Female Genital Organs. Lyon: IARS Press; 2003.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Estel R., Hackethal A., Kalder M. et al. Small cell carcinoma of the ovary of the hypercalcemic type. An analysis of clinical and prognostic aspects of a rare disease on the basis of cases published in the literature. Arch. Gynecol. Obstet. 2011; 284: 1277-82.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Young R.H., Olivia E., Scully R.E. Small cell carcinoma of the ovary, hypercalcemic type. A clinicopathologic analysis of 150 cases. Am. J. Pathol. 1994; 18: 1102-15.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Matias-Guin X., Prat J., Young R.H. et al. Human parathyroid hormone-related protein in ovarian small cell carcinoma: an immunohistochemical study. Cancer. 1994; 73 (7): 1878-84.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Eichhorn J.H., Young R.H., Scully R.E. Primary ovarian small cell carcinoma of pulmonary type. A clinicopathologic, immunohistologic, and flow cytometric analysis of 11 cases. Am. J. Surg. Pathol. 1992; 16: 926-38.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Münstedt K., Estel R., Dreyer T. et al. Small cell ovarian carcinomas - characterisation of twi rare tumor entities. Geburtsh. Frauenheilk. 2013; 73: 698-704.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Patsner B., Piver M.S., Lele S.B. Small cell carcinoma of the ovary: a rapidly lethal tumor occuring in the young. Gynecol. Oncol. 1985; 22 (2): 233-9.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Strosberg J.R., Coppola D., Klimstra O.D. et al. The MANETS consensus guidlelines for the diagnosis and management of poorly differentiated (high-grade) extra-pulmonary neuroendocrinecarcinomas. Pancreas. 2010; 39: 799-800.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Hann C.L., Rudin C.M. Management of small-cell lung cancer: incremental changes but hope for the future. Oncology (Williston Park). 2008; 22: 1486-92.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Inadome Y., Shibata T., Suzuki K. et al. Hypercalcemic type ovarian small cell carcinoma with unigue CD 34 expression. Pathol. Int. 2009; 59 (10): 766-8.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Lamovec J., Bracko M., Cerar O. Familial occurence of small-cell carcinoma of the ovary. Arch. Pathol. Lab. Med. 1995; 119 (6): 523-7.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Fignon A., Fetissof F., Calais G. et al. Small cell carcinoma of the ovary. A clinical and pathological entity-anotomo. J. Gynecol., Obstet. Biol. Reprod. 1993; 22: 372-8.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Wynn D., Everett G.D., Boothly R.A. Small cell carcinoma of the ovary with hypercalcemia causes severe pancreatitis and altered mental status. Gynecol. Oncol. 2004; 95 (3): 716-8.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Harrison M.L., Hoskins P., du Bois A. et al. Small cell carcinoma of the ovary, hypercalcemic type - analysis of combined experience and reccomendation for management. A GCIG study. Gynecol. Oncol. 2006; 100 (2): 233-8.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Saitoh-Sekiguchi M., Nakahara K., Kozimahara T. et al. Complete remission of ovarian small cell carcinoma treated with irinotecan and cisplatin: a case report. Anticancer Res. 2007; 27: 2685-8.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Dickersin G.R., Kline I.W., Scully R.E. Small cell carcinoma of the ovary with hypercalcemiia: a report of eleven cases. Cancer. 1982; 49 (1): 188-97.</mixed-citation></ref></ref-list></back></article>
