Russian Journal of OncologyRussian Journal of OncologyРоссийский онкологический журнал1028-99842412-9119Eco-Vector4033810.18821/1028-9984-2016-21-4220-224ArticlesСтатьиResearch ArticleRole of androgen receptors in various molecular subtypes of breast cancerРоль андрогеновых рецепторов в различных молекулярно-биологических подтипах рака молочной железыRyabchikovDenis A.РябчиковДенис Анатольевич

MD, PhD, senior researcher of the Department of breast cancer surgery No 5 of the Research Institute of Clinical Oncology

канд. мед. наук, старший научный сотрудник хирургического отделения № 5 НИИ клинической онкологии

dr.denisr@mail.ruVorotnikovI. KВоротниковИ. КChkhikvadzeN. VЧхиквадзеН. ВTitovK. SТитовК. СKrasnorutskiyA. VКрасноруцкийА. ВN.N. Blokhin Russian Cancer Research CenterФГБУ «Российский онкологический научный центр им. Н.Н. Блохина» Минздрава РоссииN.I. Pirogov Russian National Research Medical UniversityГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России15082016214VOL 21, NO4 (2016)ТОМ 21, №4 (2016)22022422072020Copyright ©; 2016, Eco-VectorCopyright ©; 2016, ООО "Эко-Вектор"2016Eco-VectorООО "Эко-Вектор"https://rjonco.com/1028-9984/article/view/40338

The article presents a literature review on the determination of androgen receptors in different molecular subtypes of breast cancer. The review considers the role of androgen receptors in the study of the prognosis of the disease and the search for additional approaches to the treatment of breast cancer especially for basal like subtypes.

В статье представлен обзор источников литературы, посвященных определению андрогенных рецепторов при различных молекулярных подтипах рака молочной железы. В обзоре рассмотрена роль андрогенных рецепторов в изучении прогноза заболевания и поиск дополнительных подходов к лечению рака молочной железы, в особенности при базальноподобном подтипе.

reviewbreast cancermolecular subtypesandrogen receptorstargeted therapyобзоррак молочной железымолекулярные подтипыандрогеновые рецепторытаргетная терапияАксель Е.М. Злокачественные образования молочной железы: Состояние онкологической помощи, заболеваемость и смертность. Маммология. 2006; (1): 9-15.Давыдов М.И., Аксель Е.М. Статистика злокачественных новообразований в России и странах СНГ в 2005 г. Вестник РОНЦ им. Н.Н. Блохина РАМН. 2010; 21 (2, прил. 1).Safarpour D., Tavassoli F.A. A targetable receptor-positive breast cancer subtype hidden among the triple-negative cancers. Arch. Pathol. Lab. Med. 2015; 139 (5): 612-7; doi: 10.5858/arpa.2014-0122-RAКрылов А.Ю., Крылов Ю.В. Андрогены и рак молочной железы (обзор литературы). Вестник Витебского государственного медицинского института. 2015; 14 (5): 5-15.Brys M. Androgens and androgen receptor: do they play a role in breast cancer? Med. Sci. Monit. 2000; 6 (2): 433-8.Liao D. J. Roles of androgens in the development, growth, and carcinogenesis of the mammary gland. Steroid Biochem. Mol. Biol. 2002; 80 (2): 175-89.Isola J. J. Immunohistochemical demonstration of androgen receptor in breast cancer and its relationship to other prognostic factors. J. Pathol. 1993; 170 (1): 31-5.Hu R., Dawood S., Holmes M.D., Collins L.C., Schnitt S.J., Cole K. et al. Androgen receptor expression and breast cancer survival in postmenopausal women. Clin. Cancer Res. 2011; 17 (7): 1867-74.Moinfar F., Okcu M., Tsybrovskyy O., Regitnig P., Lax S., Weybora W. et al. Androgen receptors frequently are expressed in breast carcinomas: potential relevance to new therapeutic strategies. Cancer. 2003; 98 (4): 703-11.Ogawa Y., Hai E., Matsumoto K. et al. Androgen receptor expression in breast cancer: relationship with clinicopathological factors and biomarkers. Int. J. Clin. Oncol. 2001; 13 (5): 431-5.Niemeier L.A., Dabbs D.J., Beriwal S., Striebel J.M., Bhargava R. Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. Mod. Pathol. 2010; 23 (2): 205-12.Robinson J.L., Macarthur S., Ross-Innes C.S., Tilley W.D., Neal D.E., Mills I.G., Carroll J.S. Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1. EMBO J. 2011; 30 (15): 3019-27.Sutton L.M., Cao D., Sarode V., Molberg K.H., Torgbe K., Haley B., Peng Y. Decreased androgen receptor expression is associated with distant metastases in patients with androgen receptorexpressing triple-negative breast carcinoma. Am. J. Clin. Pathol. 2012; 138 (4): 511-6.Tang D., Xu S., Zhang Q., Zhao W. The expression and clinical significance of the androgen receptor and E-cadherin in triplenegative breast cancer. Med. Oncol. 2012; 29 (2): 526-33.Panet-Raymond V., Gottlieb B., Beitel L.K., Pinsky L., Trifiro M.A. Interactions between androgen and estrogen receptors and the effects on their transactivational properties. Mol. Cell. Endocrinol. 2000; 167 (1/2): 139-50.Tokunaga E., Hisamatsu Y., Taketani K., Yamashita N., Akiyoshi S., Okada S. et al. Differential impact of the expression of the androgen receptor by age in estrogen receptor-positive breast cancer. Cancer Med. 2013; 2 (6): 763-73.Pristauz G., Petru E., Stacher E. et al. Androgen receptor expression in breastcancer patients tested for BRCA1 and BRCA2 mutations. Histopathology. 2010; 57 (6): 877-84.Shen H., Yang Y., Zhao L., Yuan J., Niu Y. Lin28A and androgen receptor expression in ER-/Her2+ breast cancer. Breast Cancer Res. Treat. 2016; 156 (1): 135-47.Wenhui Z., Shuo L., Dabei T., Ying P., Zhipeng W., Lei Z. et al. Androgen receptor expression in male breast cancer predicts inferior outcome and poor response to tamoxifen treatment. Eur. J. Endocrinol. 2014; 171 (4): 527-33.Lin F. de M., Pincerato K.M., Bacchi C.E., Baracat E.C., Carvalho F.M. Coordinated expression of oestrogen and androgen receptors in HER2-positive breast carcinomas: impact on proliferative activity. J. Clin. Pathol. 2012; 65 (1): 64-8.Qi J.P., Yang Y.L., Zhu H., Wang J., Jia Y., Liu N. et al. Expression of the androgen receptor and its correlation with molecular subtypes in 980 chinese breast cancer patients. Breast Cancer (Auckl). 2012; (6): 1-8.Agrawal A., Ziolkowski P., Grzebieniak Z., Jelen M., Bobinski P., Agrawal S. Expression of androgen receptor in estrogen receptor-positive breast cancer. Appl. Immunohistochem. Mol. Morphol. 2015; (30).Tsang J.Y., Ni Y.B., Chan S.K., Shao M.M., Law B.K, Tan P.H., Tse G.M. Androgen receptor expression shows distinctive significance in ER positive and negative breast cancers. Ann. Surg. Oncol. 2014; 21 (7): 2218-28.Castellano I., Allia E., Accortanzo V., Vandone A.M., Chiusa L., Arisio R. et al. Androgen receptor expression is a significant prognostic factor in estrogen receptor positive breast cancers. Breast Cancer Res. Treat. 2010; 124 (3): 607-17.Gucalp A., Tolaney S., Isakoff S.J., Ingle J.N., Liu M.C., Carey L.A. et al. Phase II trial of bicalutamide in patients with androgen receptor-positive, estrogen receptor-negative metastatic breast cancer. Clin. Cancer. Res. 2013; 19 (19): 5505-12.Kandil S., Westwell A.D., McGuigan C. 7-Substituted umbelliferone derivatives as androgen receptor antagonists for the potential treatment of prostate and breast cancer. Bioorg. Med. Chem. Lett. 2016; (2).Cochrane D.R., Bernales S., Jacobsen B.M., Cittelly D.M., Howe E.N., D’Amato N.C. et al. Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide. Breast Cancer Res. 2014; 16 (1): 7.Barton V.N., D’amato N.C., Gordon M.A., Lind H.T., Spoelstra N.S., Babbs B.L. et al. Multiple molecular subtypes of triplenegative breast cancer critically rely on androgen receptor and respond to enzalutamide in vivo. Mol. Cancer Ther. 2015; 14 (3): 769-78.Caiazza F., Murray A., Madden S.F., Synnott N.C., Ryan E.J., O’Donovan N. et al. Pre-clinical evaluation of the AR inhibitor enzalutamide in triple negative breast cancer cells. Endocr. Relat. Cancer. 2016; (1).Jongen L., Paridaens R., Floris G., Wildiers H., Neven P. Androgen deprivation by adrenal suppression using low-dose hydrocortisone for the treatment of breast carcinoma with apocrine features: a case report illustrating this new paradigm. Breast Cancer Res. Treat. 2016; 155 (3): 603-7.Cochrane D.R., Bernales S., Jacobsen B.M., Cittelly D.M., Howe E.N., D’Amato N.C. et al. Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide. Breast Cancer Res. 2014; 16 (1): 7.Zhu A., Li Y., Song W., Xu Y., Yang F., Zhang W. et al. Antiproliferative effect of androgen receptor inhibition in mesenchymal stem-like triple-negative breast cancer. Cell Physiol. Biochem. 2016; 38 (3): 1003-14.von Wahlde M.K., Hülsewig C., Ruckert C., Götte M., Kiesel L., Bernemann C. The anti-androgen drug dutasteride renders triple negative breast cancer cells more sensitive to chemotherapy via inhibition of HIF-1α-/VEGF-signaling. Gynecol. Endocrinol. 2015; 31 (2): 160-4.