Russian Journal of OncologyRussian Journal of OncologyРоссийский онкологический журнал1028-99842412-9119Eco-Vector63475310.17816/onco634753ReviewsНаучные обзорыReview ArticlePossibilities and prospects of using exogenous nucleases in cancer therapyВозможности и перспективы применения экзогенных нуклеаз в терапии онкологических заболеванийhttps://orcid.org/0000-0001-8619-96876117-4954FilimonovaMaria N.ФилимоноваМария Николаевна
Russian Federation

Dr. Sci. (Biology)

доктор биологических наук, старший научный сотрудник

maria.filimonova@kpfu.ruhttps://orcid.org/0000-0003-3521-59958458-4513KhadyullinaRaniya R.ХадиуллинаРания Рамилевна
Russian Federation

Cand. Sci. (Biology)

кандидат биологических наук, младший научный сотрудник

nazyrovarania@gmail.comhttps://orcid.org/0000-0003-2961-00326165-9429BulatovEmil R.БулатовЭмиль Рафаэлевич
Russian Federation

PhD (Chemistry)

PhD (Химия), ведущий научный сотрудник

chembio.kazan@gmail.comKazan (Volga Region) Federal UniversityКазанский (Приволжский) федеральный университет20112024201220242921161290108202423102024Copyright ©; 2024, Eco-VectorCopyright ©; 2024, Эко-Вектор2024Eco-VectorЭко-Векторhttps://creativecommons.org/licenses/by-nc-nd/4.0https://rjonco.com/1028-9984/article/view/634753

This literature review provides current data on the oncosuppressive effect of exogenous nucleases derived from various sources. Exogenous nucleases, such as RNase A, BS-RNase, onconase, and DNase I, are capable of degrading low-molecular extracellular DNA and RNA circulating in blood plasma, which may significantly reduce the risk of metastasis. The role of extracellular DNA and RNA in oncogenesis, as well as the impact of exogenous nucleases on their levels, have been described. The review explores the prospects of using nucleases in combination with other therapeutic methods, such as chemotherapy and radiation therapy, to enhance their effectiveness and reduce side effects. In addition, the targets and mechanisms of action of nucleases, as well as their potential for combined use with other therapeutic agents, are considered. The review concludes that exogenous nucleases have significant potential in the treatment of cancer.

В данном обзоре литературы представлены актуальные сведения об онкосупрессивном действии экзогенных нуклеаз, полученных из различных источников. Экзогенные нуклеазы, такие как РНКаза А, BS-РНКаза, онконаза и ДНКаза I, способны разрушать низкомолекулярные внеклеточные ДНК и РНК, циркулирующие в плазме крови, что может существенно снизить риск метастазирования. Описана роль внеклеточных ДНК и РНК в онкогенезе, а также влияние экзогенных нуклеаз на их количество. Обсуждаются перспективы использования нуклеаз в сочетании с другими терапевтическими методами, такими как химиотерапия и лучевая терапия, для повышения их эффективности и снижения побочных эффектов. Кроме того, рассмотрены мишени и механизмы действия нуклеаз, а также возможность их применения в сочетании друг с другом и с другими терапевтическими средствами. Сделан вывод о потенциальной эффективности применения экзогенных нуклеаз в терапии онкологических заболеваний.

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