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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Oncology</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Oncology</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский онкологический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1028-9984</issn><issn publication-format="electronic">2412-9119</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">646863</article-id><article-id pub-id-type="doi">10.17816/onco646863</article-id><article-id pub-id-type="edn">JNWNDP</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case Reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Results of successful application of radiofrequency ablation in the treatment of hepatocellular carcinoma (HCC)</article-title><trans-title-group xml:lang="ru"><trans-title>Результаты успешного применения радиочастотной аблации при лечении гепатоцеллюлярного рака (ГЦР)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1879-6978</contrib-id><contrib-id contrib-id-type="spin">3710-8052</contrib-id><name-alternatives><name xml:lang="en"><surname>Trifanov</surname><given-names>Vladimir S.</given-names></name><name xml:lang="ru"><surname>Трифанов</surname><given-names>Владимир Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Assistant Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, доцент</p></bio><email>trifan1975@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1391-0516</contrib-id><contrib-id contrib-id-type="spin">1412-8811</contrib-id><name-alternatives><name xml:lang="en"><surname>Budurova</surname><given-names>Marina D.</given-names></name><name xml:lang="ru"><surname>Будурова</surname><given-names>Марина Дмитриевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>m.budurova@rambler.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0495-8585</contrib-id><contrib-id contrib-id-type="spin">3108-1094</contrib-id><name-alternatives><name xml:lang="en"><surname>Kamalova</surname><given-names>Milyausha A.</given-names></name><name xml:lang="ru"><surname>Камалова</surname><given-names>Миляуша Анасовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>milyausha.kamalova.97@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2427-9232</contrib-id><contrib-id contrib-id-type="spin">5619-4469</contrib-id><name-alternatives><name xml:lang="en"><surname>Chernichenko</surname><given-names>Maria A.</given-names></name><name xml:lang="ru"><surname>Черниченко</surname><given-names>Мария Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>mashustic04@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1703-9115</contrib-id><name-alternatives><name xml:lang="en"><surname>Grishin</surname><given-names>Nikolay A.</given-names></name><name xml:lang="ru"><surname>Гришин</surname><given-names>Николай Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>grishinlap@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">National Medical Research Radiological Center</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр радиологии</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian University of Medicine</institution></aff><aff><institution xml:lang="ru">Российский университет медицины</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-09-02" publication-format="electronic"><day>02</day><month>09</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-10-19" publication-format="electronic"><day>19</day><month>10</month><year>2025</year></pub-date><volume>30</volume><issue>2</issue><issue-title xml:lang="en">Russian Journal of Oncology</issue-title><issue-title xml:lang="ru">Российский онкологический журнал</issue-title><fpage>144</fpage><lpage>151</lpage><history><date date-type="received" iso-8601-date="2025-01-30"><day>30</day><month>01</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-07-08"><day>08</day><month>07</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-10-19"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjonco.com/1028-9984/article/view/646863">https://rjonco.com/1028-9984/article/view/646863</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND</bold><bold>:</bold> One of the surgical treatment methods for hepatocellular carcinoma is energy-based tumor ablation, indicated in patients with BCLC stage<bold> </bold>0 and stage<bold> </bold>A disease when liver resection or transplantation is not feasible.</p> <p><bold>CASE DESCRIPTION:</bold> A 72-year-old patient with hepatocellular carcinoma, cT1bN0M0 (stage IB), underwent percutaneous radiofrequency ablation because of severe comorbidities, including cirrhosis secondary to nonalcoholic steatohepatitis, Child-Pugh class B (7 points), portal hypertension, dilatation of the portal venous system, portosystemic shunts, grade 1 ascites, splenomegaly, and grade 2 esophageal varices (endoscopic ligation of grade 2 varices was performed in 2018), as well as type 2 diabetes mellitus. Chest and abdominal computed tomography with intravenous contrast at 3, 6, and 9 months after the procedure revealed no evidence of tumor progression.</p> <p><bold>CONCLUSION</bold><bold>:</bold> At the P. Hertsen Moscow Oncology Research Institute, the results of successful radiofrequency ablation in hepatocellular carcinoma were analyzed. The method demonstrated favorable short-term outcomes, a minimal number of complications, and favorable long-term outcomes, with overall 5-year survival reaching 94% of cases and overall 10-year survival 32.3% of cases, including patients with severe comorbidities. Over the past 10 years, at the P. Hertsen Moscow Oncology Research Institute, radiofrequency ablation has been used as an independent treatment modality in 5 patients. Overall 3-year recurrence-free survival was achieved in 80% of patients (4 patients), and overall 5-year survival in 20% of patients (1 patient).</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Один из методов хирургического лечения гепатоцеллюлярного рака — энергетическая абляция опухоли, выполняемая пациентам с данным диагнозом в стадии BCLC 0 и BCLC A при невозможности резекции или трансплантации печени.</p> <p><bold>Описание клинического случая.</bold> Пациенту 72 лет с клиническим диагнозом «гепатоцеллюлярный рак» сT1bN0M0 (IB стадия) проведено лечение методом радиочастотной термоабляции в связи с наличием тяжёлой сопутствующей патологии: цирроза печени в исходе неалкогольного стеатогепатита класса В по шкале Child-Pugh (7 баллов), портальной гипертензии, расширения вен портальной системы, портосистемных шунтов, асцита 1-й степени, спленомегалии, варикозного расширения вен пищевода 2-й степени (с проведением эндоскопического лигирования варикозного расширения вен пищевода 2-й степени в 2018 г.), а также сахарного диабета 2-го типа. По результатам компьютерной томографии органов грудной клетки и брюшной полости с внутривенным контрастированием через 3, 6 и 9 месяцев наблюдения в послеоперационном периоде данных о прогрессировании опухолевого процесса не обнаружили.</p> <p><bold>Заключение.</bold> В Московском научно-исследовательском онкологическом институте имени П.А. Герцена (МНИОИ им. П.А. Герцена) проанализированы результаты успешного применения радиочастотной термоабляции при гепатоцеллюлярном раке. Метод демонстрирует хорошие непосредственные результаты, минимальное количество осложнений, хорошие отдалённые результаты лечения гепатоцеллюлярного рака с достижением 5-летней общей выживаемости до 94% случаев, 10-летней общей выживаемости в 32,3% случаев, в том числе у пациентов с выраженной сопутствующей патологией. За последние 10 лет в МНИОИ им. П.А. Герцена метод радиочастотной термоабляции применён как самостоятельный метод лечения у 5 пациентов. Общей 3-летней безрецидивной выживаемости достигли 80% пациентов (4 пациента), общей 5-летней выживаемости — 20% (1 пациент).</p></trans-abstract><kwd-group xml:lang="en"><kwd>case report</kwd><kwd>hepatocellular carcinoma</kwd><kwd>radiofrequency ablation</kwd><kwd>liver cirrhosis</kwd><kwd>non-alcoholic steatohepatitis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>клинический случай</kwd><kwd>гепатоцеллюлярный рак</kwd><kwd>радиочастотная термоабляция</kwd><kwd>цирроз печени</kwd><kwd>неалкогольный стеатогепатит</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Salgia R, Mendiratta V. The Multidisciplinary Management of Hepatocellular Carcinoma. Clinical Liver Disease. 2021;17(6):405–408. doi: 10.1002/cld.1068</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Rahib L, Wehner MR, Matrisian LM, Nead KT. Estimated Projection of US Cancer Incidence and Death to 2040. 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