Issledovanie diagnosticheskoy chuvstvitel'nosti novykh opukholeassotsiirovannykh koprologicheskikh markerov pri kolorektal'nom rake

The authors studied the sensitivity and specificity of 3 new tests detecting human hemoglobin (hHb), the hemoglobin-haptoglobin (hHb/Hp) complex, and tumor pyruvate kinase (fTu M2-PK) in feces to diagnose colorectal cancer (CRC). The investigation included patients with CRC (n = 78), ulcerative colitis (UC) (n = 21), enteric polyps (n = 12), and apparently healthy donors (n = 47). The sensitivity of the hHb test system was highest (88.5%) in diagnosing CRC while the hHB/Hp and fTu M2-PK tests were slightly lower (76.9 and 77.9%, respectively). These tests revealed UC with a slightly lower sensitivity in the same order: 76.2, 57.1, and 66.7%, respectively. The feces from the patients with enteric polyps were marker positive in some cases. In donors, the specificity of the hHb and hHb/Hp tests was high (93.6 and 100%, respectively) and that of the fTu M2-PK test system was slightly lower (81.1%).

hHb, hHb/Hp, fTu M2-PK, colorectal cancer, coprotests, hHb, hHb/Hp, fTu M2-PK