Morphological signs of colorectal cancer metastases to the liver

The paper analyzes the results of a morphological study of liver metastases from colorectal cancer for their treatment. The sizes, quantity, and localization of nodules cannot be used as diagnostically significant criteria for colorectal cancer metastasis to the liver. The combination of the degree of differentiation and histological structure of the secondary tumor parenchyma with the prevailing number of papillary cell units in the cytological specimens may serve as a diagnostically significant morphological sign of colorectal cancer liver metastasis. High-prismatic and cylindric tumor cells preserving their secretory activity can serve as cytological criteria for colorectal cancer metastases to the liver. Colorectal cancer liver metastatic cells preserved cytokeratin 20 expression inherent in primary cancer cells in 90.9% of cases and carcinoembryonic antigen expression in 54.5%.

colorectal cancer metastases, tumor parenchyma, liver