电邮这篇文章 Use of monoclonal antibodies in drug therapy for
- 作者: Bolotina LV1, Paychadze AA1, Koroleva LA1, Bolotina LV1, Paichadze AA1, Koroleva LA1
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- 期: 卷 16, 编号 3 (2011)
- 页面: 53-56
- 栏目: Articles
- ##submission.dateSubmitted##: 22.07.2020
- ##submission.datePublished##: 15.06.2011
- URL: https://rjonco.com/1028-9984/article/view/39878
- DOI: https://doi.org/10.17816/onco39878
- ID: 39878
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The paper gives the results of international studies of a role of targeted therapy for disseminated colorectal cancer (DCRC). It considers three drugs from this group - cetuximab (erbitux), panitumumab (vectibix), and bevacizumab (avastin). Erbitux demonstrated its activity against DCRC with EGFR receptor hyperexpression and KRAS wide-type and its ability to potentiate the antitumor activity of irinotecan. In DCRC patients without K-RAS mutation, the use of vectibix could significantly increase objective response rates, disease stabilization, and survival to progression as compared with the similar parameters during symptomatic therapy. Avastin therapy leads to a reduction in tumor growth and increases in overall survival (to 25 months) time to disease progression (by 20-25%) as compared to chemotherapy only.
参考
- Amado R., Wolf M., Peeters M. et al. // J. Clin. Oncol. - 2008. - Vol. 26. - P. 1626-1634.
- Avastin Package Insert. - San Francisco: Genentech; 2004 Feb.
- Bouganim N., Kavan P., Eid M. et al. // J. Clin. Oncol. - 2009. - Vol. 27 (suppl.). - Abstr. 5027.
- Bokemeyer C., Bondarenko I., Hartmann J. T. et al. // J. Clin. Oncol. - 2008. - Vol. 26 (suppl.). - Abstr. 4000.
- Cunningham D., Humblet Y. et al. // N. Engl. J. Med. - 2004. - Vol. 351. - P. 337-345.
- Damjanov N., Meropol N. J. Oncology. - 2004. - P. 479-503.
- Douillard J., Siena S., Cassidy J. et al. // Eur. J. Cancer. - 2009. - Vol. 7, N 3 (suppl.). - Abstr. 10LBA.
- Folprecht G. et al. // ASCO GI Symposium. - 2004. - Abstr. 283.
- Giantonio B. J., Catalano P. J., Meropol N. J. et al. // Proc. Am. Soc. Clin. Oncol. - 2005. - Vol. 23. - P. 259s. - Abstr. 2.
- Hochster H. S., Welles L., Hart L. et al. // Proc. Am. Soc. Clin. Oncol. - 2005. - Vol. 23. - P. 259s. - Abstr. 3515.
- Hurwitz H., Fehrenbacher L., Hainsworth J. et al. // Gastrointestinal Cancers Symposium. - San Francisco, 2004. - P. 182. - Abstr. 286.
- Hurwitz H., Fehrenbacher L., Novotny W. et al. // N. Engl. J. Med. - 2004. - Vol. 350. - P. 2335-2342.
- Jain R. K. // Nat. Med. - 2001. - Vol. 7. - P. 987-989.
- Kabbinavar F. et al. // J. Clin. Oncol. - 2003. - Vol. 21. - P. 60-65.
- Lenz H. J., Mayer R. J. et al. // J. Clin. Oncol. - 2005. - Vol. 23 (16s). - Abstr. 3536.
- Peeters M., Price T., Hotko Y. et al. // Eur. J. Cancer. - 2009. - Vol. 7, N 3. (suppl.). - Abstr. 14LBA.
- Presta L. G. et al. // Cancer Res. - 1997. - Vol. 57. - P. 4593-4599.
- Prewett M. et al. // Clin. Cancer Res. - 2002. - Vol. 8. - P. 994-1003.
- Rosenberg M. et al. // Symposium ASCO. - 2002. - Abstr. 536.
- Rougier P. et al. // J. Clin. Oncol. - 2004. - Vol. 22 (14s). - Abstr. 3513.
- Saltz L. B., Cox J. V., Blanke C. et al. // N. Engl. J. Med. - 2000. - Vol. 343. - P. 905-914.
- Saltz L., Meropol N. J. et al. // J. Clin. Oncol. - 2004. - Vol. 22. - P. 1201-1208.
- Saltz L., Lenz H., Hochster H. et al. // Proc. Am. Soc. Clin. Oncol. - 2005. - Vol. 23. - P. 259s. - Abstr. 3508.
- Saltz L., Clarke S., Diaz-Rubio E. et al. // J. Clin. Oncol. - 2007. - Vol. 25 (18s; suppl.). - Abstr. 4028.
- Souglakos J., Kalykaki A. et al. // Ann. Oncol. - 2006. - Vol. 17, N 1. - P. 1-6.
- Van Cutsem E. et al. // Ann. Oncol. - 2004. - Vol. 15 (suppl. 3). - Abstr. 339P.
- Van Cutsem E., Nowacki M. et al. // ASCO. - 2007. - Abstr. 4000.
- Van Cutsem E., Peeters M., Siena S. et al. // J. Clin. Oncol. - 2007. - Vol. 25. - P. 1658-1664.
- Wein A. et al. // Ann. Oncol. - 2001. - Vol. 12. - P. 1721- 1727.
- Wildiers H., Guetens G., De Boeck G. et al. // Br. J. Cancer. - 2003. - Vol. 88. - P. 1979-1986.
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