Toll-like receptor gene polymorphisms in a population-based study of HIV and tuberculosis patients from Eastern Europe and Central Asia

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Abstract

Genetic diversity of human populations is determined by polymorphic variants of immune response genes and can be linked to the variation in responses to infectious agents. This study compared allele and genotype frequencies of polymorphic variants of TLR1, TLR2, TLR4, TLR6 and TLR8 genes between samples from Eastern Europe and Central Asia. We included 680 unrelated individuals from Eastern Slavic (n = 308), Armenian (n = 137), Tajik (n = 138) and Kyrgyz (n = 97) samples of patients with confirmed diagnoses of HIV and tuberculosis. The international 1000 Genomes Project data - samples of Caucasians (EUR) and countries of eastern (EAS) and southern (SAS) Asia – were used for comparison. Despite the lack of genetic diversity and population differences in allele frequencies of the analyzed genes, the samples differed in a number of loci both from each other and from EAS, SAS samples.

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About the authors

S. А. Salamaikina

Central Research Institute of Epidemiology Federal service for surveillance on consumer rights protection and human wellbeing; Moscow institute of physics and technology

Author for correspondence.
Email: salamaykina@cmd.su

национальный исследовательский университет

Russian Federation, Moscow, 111123; Dolgoprudny, 141701

V. I. Korchagin

Central Research Institute of Epidemiology Federal service for surveillance on consumer rights protection and human wellbeing

Email: salamaykina@cmd.su
Russian Federation, Moscow, 111123

К. О. Mironov

Central Research Institute of Epidemiology Federal service for surveillance on consumer rights protection and human wellbeing

Email: salamaykina@cmd.su
Russian Federation, Moscow, 111123

Е. I. Kulabukhova

Central Research Institute of Epidemiology Federal service for surveillance on consumer rights protection and human wellbeing; Peoplesʹ Friendship University of Russia (RUDN University)

Email: salamaykina@cmd.su
Russian Federation, Moscow, 111123; Moscow, 117198

V. N. Zimina

Kemerovo state medical university of the ministry of health of the Russian Federation

Email: salamaykina@cmd.su
Russian Federation, Kemerovo, 650056

А. V. Kravtchenko

Central Research Institute of Epidemiology Federal service for surveillance on consumer rights protection and human wellbeing

Email: salamaykina@cmd.su
Russian Federation, Moscow, 111123

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2. Fig. 1. Frequency distribution of genotypes of polymorphic variants of TLR genes in the studied samples: a – rs5743551 (TLR1), b – rs5743708 (TLR2), c – rs3804100 (TLR2), d – rs4986790 (TLR4), d – rs5743810 (TLR6), e – rs3764880 (TLR8).

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