Search for ethnospecific risk markers for the development of paranoid schizophrenia in bashkirs based on the results of a genome-wide association analysis

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Schizophrenia is now known to be a multifactorial disease in which both genetic and environmental factors play a role. In recent years, mainly through the use of genome-wide association studies (GWAS), many molecular genetic processes have been identified that increase susceptibility to schizophrenia. The aim of this study was to study genetic risk factors for the development of schizophrenia in a genome-wide association analysis (GWAS) in Bashkirs from the Republic of Bashkortostan. The studied sample consisted of 139 patients with paranoid schizophrenia and 204 healthy individuals. Whole genome genotyping of DNA samples was carried out on the PsychChip biochip, which included 610,000 single nucleotide polymorphic variants (SNPs).

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作者简介

A. Gareeva

Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences; Kemerovo State University; Russian Medical Academy of Continuing Professional Education of the Ministry of Health of Russia

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Email: annagareeva@yandex.ru
俄罗斯联邦, Ufa, 450054; Kemerovo, 650000; Moscow, 125993

参考

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2. Fig. 1. Graphical representation of the results of the genome-wide association analysis of 395,832 SNPs with paranoid schizophrenia in Bashkirs (Manhattanplot). The X-axis shows the chromosomal localization of the SNPs, and the Y-axis shows the negative decimal logarithm of the p-value significance level.

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