Synthesis and investigation of sorption properties of Ca3La6(SiO4)6 biocomposite for targeted delivery of 5-fluorouracil

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Abstract

The paper presents the synthesis of dispersed Ca3La6(SiO4)6 biocomposite material by processing calcium silicate sol with the addition of 0.1, 0.3 and 0.7 mol La3+ under hydrothermal conditions. The composition, morphology and structure of the biocomposite were studied by XRF, SEM, and EMF methods, and the reaction products CaSiO3, CaLa4(SiO4) were determined 3O and Ca3La6(SiO4)6 depending on the concentration of La3+ The structural characteristics of biocomposite powders with different La3+ contents have been studied by BET and DFT methods. Their sorption characteristics with respect to 5-fluorouracil were studied depending on the pH of the medium, the maximum sorption capacity is 0.768 mg/g at pH 3 for a sample of Ca3La6(SiO4)6 biocomposite with the addition of 0.3 mol La3+. Additionally, the biocompatible properties of biocomposite samples under conditions of their contact with artificial blood plasma were evaluated by establishing key changes in their composition, morphology and structure during the formation of the bioactive phase of apatite on the accessible surface of the samples. The results hold promise for further research in the development of new sorption materials, including biomaterials for targeted drug delivery, with the potential for practical application.

About the authors

O. O. Shichalin

Far Eastern Federal University

Author for correspondence.
Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

O. V. Kapustina

Far Eastern Federal University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

Z. E. Kornakova

Far Eastern Federal University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

S. S. Gribanova

Far Eastern Federal University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

V. Y. Mayorov

Far Eastern Federal University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

A. N. Fedorets

Far Eastern Federal University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

A. O. Lembikov

Far Eastern Federal University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

V. V. Vasilyeva

Far Eastern Federal University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

I. Y. Buravlev

Far Eastern Federal University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

V. I. Apanasevich

Pacific State Medical University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

E. K. Papynov

Far Eastern Federal University

Email: oleg_shich@mail.ru
Russian Federation, Vladivostok, 690922

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