Determination Of Optimal Conditions For Template Sol-Gel Synthesis For The Formation Of Antibacterial Materials

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Abstract

One of the current global problems is the increasing resistance of microorganisms to antibacterial agents and the emergence of associated infections. Therefore, the synthesis of new hybrid materials capable of resisting bacteria is necessary. In this work, loading platforms for antibacterial material based on tetraethoxysilane were formed using yeast cells Ogataea polymorpha BKM Y-2559 and Cryptococcus curvatus VKM Y-3288 as templates under conditions of acid and alkaline hydrolysis. Using scanning electron microscopy, it was shown that an alkaline environment is most optimal when using yeast cells as templates for the formation of a porous material. The surface-active properties of a number of quaternary ammonium compounds were studied using the tensometry method to select the optimal template for the production of antibacterial materials in one stage.

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About the authors

E. A. Lantsova

Tula State University

Author for correspondence.
Email: e.a.lantsova@tsu.tula.ru
Russian Federation, Tula, 300012

M. A. Bardina

Tula State University

Email: e.a.lantsova@tsu.tula.ru
Russian Federation, Tula, 300012

E. A. Saverina

Tula State University

Email: e.a.lantsova@tsu.tula.ru
Russian Federation, Tula, 300012

O. A. Kamanina

Tula State University

Email: e.a.lantsova@tsu.tula.ru
Russian Federation, Tula, 300012

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2. Fig.

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3. Fig. 1. The scheme of the traditional synthesis of sol-gel matrices with subsequent loading of an antimicrobial drug (a) and synthesis of a drug using an HOUR as a template (b) [20].

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4. Fig. 2. Acid hydrolysis in the absence of cells: a – bar-label 50 microns, b– bar-label 5 microns; c, d – acid hydrolysis in the presence of Ogataea polymorpha cells (bar-label 5 microns), d – alkaline hydrolysis in the absence of cells (bar-label 10 microns), e – alkaline hydrolysis in the presence of Cryptococcus curvatus cells (bar label 5 microns).

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5. Fig. 3. Structures of the compounds studied in the work. Compounds 1a–1g were first described in [26], compound 2 in [27].

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6. Fig. 4. Curves of dependence of MFN on the concentration of a solution of a series of compounds 1 (a), compounds 2 (b).

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