Synthesis of triethylammonium salts of amidine derivatives of closo-borate anions [B10H10]2– and [B12H12]2– and investigation of their cytotoxic properties

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Abstract

A series of amidine derivatives of closo-deca- and dodecaborate anions with triethylammonium cations were obtained in this work. The structure of the compounds was established by multinuclear NMR spectroscopy, ESI-mass spectrometry. Cytotoxicity was investigated for all obtained compounds by MTT method on 4 cell lines. It was shown that the nature of the cation does not affect the cytotoxicity of substituted closo-borates.

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About the authors

M. N. Ryabchikova

National Research University Higher School of Economics

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 101000

A. V. Nelyubin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

I. N. Klyukin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

N. Yu. Karpechenko

Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation; Pirogov Russian National Research Medical University

Email: zhdanov@igic.ras.ru

Department of Medicinal Chemistry and Toxicology

Russian Federation, Moscow, 115522; Moscow, 117513

A. P. Zhdanov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Author for correspondence.
Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

K. Yu. Zhizhin

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

N. T. Kuznetsov

Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences

Email: zhdanov@igic.ras.ru
Russian Federation, Moscow, 119991

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