Quaternization of Methyl Picolinate with Some Phenacyl Bromides. Synthesis of DL-Baikiain Alkaloid

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Abstract

By fusing methyl picolinate with phenacyl bromides, the corresponding phenacyl salts were obtained, cyclization of which in acetic anhydride led to previously undescribed 3-aryl-1H-pyrido[2,1-c][1,4]oxazinium bromides. Reduction of the quaternary salts of methyl picolinate followed by acid hydrolysis leads to the alkaloid DL-baikiain.

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About the authors

D. A. Lomov

L. M. Litvinenko Institute of Physical Organic and Coal Chemistry

Author for correspondence.
Email: lomov_dmitrii@mail.ru
Russian Federation, Donetsk

M. G. Abramyants

L. M. Litvinenko Institute of Physical Organic and Coal Chemistry

Email: lomov_dmitrii@mail.ru
Russian Federation, Donetsk

O. O. Zaporozhets

L. M. Litvinenko Institute of Physical Organic and Coal Chemistry

Email: lomov_dmitrii@mail.ru
Russian Federation, Donetsk

T. M. Pekhtereva

L. M. Litvinenko Institute of Physical Organic and Coal Chemistry

Email: lomov_dmitrii@mail.ru
Russian Federation, Donetsk

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