Synthesis of azole derivatives of 1,2,3-dithiazole-5-imines and study of their fungicidal

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Abstract

A three-stage method was proposed for the synthesis of new 4-[4-(2-azolylethyl)piperazine-1-yl]- N -aryl-5 H 1,2,3-dithiazole-5-imines. This approach includes the reaction of Appel salt with anilines to produce 1,2,3-dithiazole-5-imines, which were converted into 4-[(4-chloroethyl)piperazine-1-yl]-5 H -1,2,3-dithiazole-5-imines, alkylating azoles at the final stage. The high fungicidal activity of target compounds and intermediate 4-chloro N -aryl-1,2,3-dithiazole-5-imines was shown in vitro tests versus six species of phytopathogenic fungi.

About the authors

G. V. Tsaplin

D. I. Mendeleev Russian University of Chemical Technology

Email: tsaplin.g.v@muctr.ru

E. I. Bashkalova

D. I. Mendeleev Russian University of Chemical Technology

A. L. Alekseenko

D. I. Mendeleev Russian University of Chemical Technology;N. D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

S. V. Popkov

D. I. Mendeleev Russian University of Chemical Technology;All-Russian Research Institute of Phytopathology

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