Synthesis, Structure, and Study of the Cytotoxic Activity of Zinc(II) Complex with 5-Benzyltetrazole and 1,10-Phenanthroline

E. A. Ermakova; Ермакова Е. А.; Yu. A. Golubeva; Голубева Ю. А.; K. S. Smirnova; Смирнова К. С.; L. S. Klyushova; Клюшова Л. С.; I. V. El’tsov; Ельцов И. В.; E. V. Lider; Лидер Е. В.

doi:10.31857/S0132344X22600631

Synthesis, Structure, and Study of the Cytotoxic Activity of Zinc(II) Complex with 5-Benzyltetrazole and 1,10-Phenanthroline

Authors: Ermakova E.A.¹, Golubeva Y.A.¹, Smirnova K.S.¹, Klyushova L.S.², El’tsov I.V.³, Lider E.V.¹
Affiliations:
1. Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
2. Research Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia
3. Novosibirsk National Research State University, Novosibirsk, Russia
Issue: Vol 49, No 9 (2023)
Pages: 582-589
Section: Articles
URL: https://rjonco.com/0132-344X/article/view/667484
DOI: https://doi.org/10.31857/S0132344X22600631
EDN: https://elibrary.ru/WAENNY
ID: 667484

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Abstract
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Abstract

The complex [Zn(Phen)(H2O)L2] (I), where HL is 5-benzyltetrazole, Phen is 1,10-phenanthroline,
was synthesized. The compound was characterized by standard physicochemical methods (elemental
analysis, powder X-ray diffraction, IR spectroscopy). According to X-ray diffraction data (CCDC no.
2220597), zinc coordination environment in the crystal structure of I corresponds to a distorted trigonal
bipyramid. The ligand HL is monodentate and is coordinated via tetrazolate ring nitrogen. The stability of
complex I was studied by NMR spectroscopy in DMSO. The cytotoxic properties of the compound were
assessed against HepG-2 (hepatocellular carcinoma) and MRC-5 (noncancerous human fibroblasts) cells.
Complex I exhibits weak cytotoxic properties in the studied concentration range (1–100 μM).

Keywords

zinc, crystal structure, cytotoxicity, MRC-5

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