Delayed Drug Release Films Based on MIL-100(Fe) Metal-Organic Framework

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Abstract

Biocompatible metal-organic framework MIL-100(Fe) was used as a container for a model hydrophobic active pharmaceutical ingredient, ibuprofen, in composite films based on gelatin, pectin, and kappacarrageenan. According to powder X-ray diffraction and scanning electron microscopy data, the metal-organic framework retained the crystal structure and its particles were uniformly distributed throughout the hydrocolloid matrix. Testing of the obtained film materials under simulated biological conditions using chromatography – mass spectrometry analysis showed that they are applicable as a dosage form for slow release of active pharmaceutical ingredients.

About the authors

A. M. Pak

Nesmeyanov Institute of Organic Element Compounds, Russian Academy of Sciences; Moscow Institute of Physics and Technology (National Research University)

Email: novikov84@gmail.com
Russian Federation, Moscow; Moscow

T. N. Volkhina

Mendeleev University of Chemical Technology of Russia

Email: novikov84@gmail.com
Russian Federation, Moscow

Yu. V. Nelyubina

Nesmeyanov Institute of Organic Element Compounds, Russian Academy of Sciences; Moscow Institute of Physics and Technology (National Research University)

Email: novikov84@gmail.com
Russian Federation, Moscow; Moscow

V. V. Novikov

Moscow Institute of Physics and Technology (National Research University)

Author for correspondence.
Email: novikov84@gmail.com
Russian Federation, Moscow

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