Oogonial stem cells in the ovaries of adult birds

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Abstract

In vertebrates, oogonial stem cells (OSCs) contribute to oogenesis in some fish, amphibians, and reptiles, enabling the production of new oocytes during each reproductive cycle. Classical literature from the 19th and 20th centuries established the prevailing notion that, in mammals and birds, the ovarian reserve is formed exclusively during embryogenesis, with OSCs absent in postnatal and adult ovaries. However, in 2004, OSCs were first identified in the ovaries of adult female mice, challenging the long-standing dogma that postnatal neo-oogenesis is impossible in mammals. Despite an increasing number of studies, this issue remains controversial. Advances in molecular and cellular techniques have significantly expanded our understanding of oogenesis across various animal groups. Notably, a recent study of adult chicken ovaries identified the presence of OSCs, further questioning traditional assumptions about ovarian biology in birds. In this review, we examine the evidence for postnatal oogenesis in this group of vertebrates.

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About the authors

Yu. A. Shalutina

St. Petersburg State University

Email: svetlana.galkina@spbu.ru

Department of Embryology

Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

O. D. Takki

St. Petersburg State University

Email: svetlana.galkina@spbu.ru

Department of Embryology

Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

M. M. Kulak

St. Petersburg State University

Email: svetlana.galkina@spbu.ru

Department of Embryology

Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

E. R. Gaginskaya

St. Petersburg State University

Email: svetlana.galkina@spbu.ru

Department of Embryology

Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

S. A. Galkina

St. Petersburg State University

Author for correspondence.
Email: svetlana.galkina@spbu.ru

Department of Embryology

Russian Federation, Universitetskaya nab. 7/9, St. Petersburg, 199034

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2. Fig. 1. Immunohistochemical detection of SSEA-1 protein, a marker of primordial germ cells, in the ovary of a mature (6-month-old) zebra finch. Cells positive for the SSEA-1 marker are outlined. Scale bar is 50 µm on the slide.

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