Email this article FUNCTIONAL PARAMETERS OF ISOLATED RAT MYOCARDIUM AFTER THE COURSE OF DIOCTYL TEREPHTHALATE
- Authors: Laptev D.S.1, Petunov S.G.1, Nechaykina O.V.1, Bobkov D.V.1
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Affiliations:
- Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
- Issue: No 5 (2019)
- Pages: 21-25
- Section: Articles
- Published: 28.10.2019
- URL: https://rjonco.com/0869-7922/article/view/641181
- DOI: https://doi.org/10.36946/0869-7922-2019-5-21-25
- ID: 641181
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Abstract
The cardiotoxic effect of long-term (within 60 days) inhalation of dioctyl terephthalate at doses of 3,4; 18,6 and 96.8 mg/m3 has been studied on a model of isolated rat heart. The course administration of dioctyl terephthalate does not change the contractile activity and adrenoreactivity of the rat heart. Dioctyl terephthalate at doses of 96.8 mg/m3 and 18,6 mg/m3 contributes to the development of changes in the electrical activity of the myocardium, leading to an increase in the amplitude of the R and T waves, lengthening the QT interval and shortening the PR interval, which can cause cardiac arrhythmias in ischemic conditions. Adrenoreactivity of isolated heart does not change under the influence of dioctyl terephthalate. The data obtained indicate that the dioctyl terephthalate at concentration of 3,4 mg/m3 is safe for heart.
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About the authors
D. S. Laptev
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Author for correspondence.
Email: lapden@mail.ru
Laptev Denis Sergeyevich
188663, Leningrad region
Russian FederationS. G. Petunov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: sergey~petunov@mail.ru
Petunov Sergey Gervasiyevich
188663, Leningrad region
Russian FederationO. V. Nechaykina
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: olga2278@mail.ru
Nechaykina Olga Valeryevna
188663, Leningrad region
Russian FederationD. V. Bobkov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, FMBA
Email: bdv21@yandex.ru
Bobkov Dmitriy Vladimirovich
188663, Leningrad region
Russian FederationReferences
- Mamonov R.A., Fedotova L.A., Pechnikova I.A., Potapchenko T.D. Toxicity of dioctylterephthalate. Toxicological Bulletin. 2018, 6, 153, Pp. 47-48 (in Russian).
- LaptevD.S. PetunovS.G., BobkovD.V., RadilovA.S. The influence of B-endorphin on the functional activity of the isolated heart of rat. The role of p- and 5-opioid receptors. Regional blood circulation and microcirculation. 2015, 3, 55, Pp. 66-71 (in Russian).
- Nechaykina O.V., Petunov S.G., Radilov A.S. Effect of р-endorphin on contractile activity of isolated rat lymph vessels. Regional blood circulation and microcirculation. 2013, 3, 47, Pp. 64-70 (in Russian).
- Posnack N.G., Swift L.M., Kay M.W., Lee N.H., Sarvazyan N. Phthalate exposure changes the metabolic profile of cardiac muscle cells. Environ Health Perspect. 2012, 120, 9, Pp. 1243-51.
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