STUDY OF THE TOXIC PROPERTIES OF 3-CHLOROPROPYL AND 6-CHLOROHEXYL ACRYLATES WITH JUSTIFICATION OF APPROXIMATELY SAFE LEVEL OF EXPOSURE IN THE AIR OF THE WORKING AREA

Cover Page

Cite item

Full Text

Abstract

The article presents the results of the study on toxicity of 3-chloropropyl and 6-chlorohexyl acrylates in acute (at the level of lethal and sublethal doses and concentrations) and subchronic experiments (dose-monotone intake at the level of 0.1 DL50 per os for 45 days), which allowed to justify the value of approximately safe levels of exposure for chemicals in the air of the working area. Scientifically substantiated values of approximately safe exposure levels for 3-chloropropyl acrylate at 5 mg/m3 and for 6-chlorohexyl acrylate at 2 mg/m3 have been established.

About the authors

S. I. Sychik

Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus

Author for correspondence.
Email: rspch@rspch.by

Sychik Sergei Ivanovich

220012, Minsk Belarus

V. M. Vasilkevich

Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus

Email: sabas2004@mail.ru

Vasilkevich Vadim Michailovich

220012, Minsk Belarus

R. V. Bogdanov

Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus

Email: 7_rus@tut.by

Bogdanov Ruslan Valerievich

220012, Minsk

Belarus

L. M. Bondarenko

Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus

Email: fake@neicon.ru

Bondarenko Ljudmila Mihailovna

220012, Minsk

Belarus

A. V. Bujnickaja

Scientific Practical Centre of Hygiene, Ministry of Health of the Republic of Belarus

Email: fake@neicon.ru

Bujnickaja Anna Vasil’evna

220012, Minsk

Belarus

References

  1. Methodological instructions for the experimental substantiation of the MPC of microorganisms-producers and the finished forms of preparations containing them in the objects of production and the environment: methodological instructions No 5789/ 1-91. Moscow; 1993 (in Russian).
  2. Belen'kiy M.L. Elements of quantitative evaluation of the pharmacological effect. Leningrad: Medgiz; 1963 (in Russian).
  3. Requirements for the formulation of experimental studies on the study of allergenic properties and the justification of the maximum allowable concentrations of chemical allergens in the air of the working area and atmosphere: methodological instructions No 1.1.11-12-5-2003. In: Filonov V.P., Sokolov S.M., eds. Collection of official documents on occupational medicine and production. Minsk; 2004. 133-56 (in Russian).
  4. State Standard 12.1.007-76. SSTB. Noxious substances. Classification and general safety requirements. Minsk: BelGISS; 2008 (in Russian).
  5. Izmerov N.F., Sanotskiy I.V., Sidorov K.K. Toxicometry parameters of industrial poisons upon single exposure: a handbook. Moscow: Meditsina; 1977 (in Russian).
  6. Experimental justification and calculation of hazardous materials in the air of the working area Experimental justification and calculation of the indicative safe exposure levels of harmful substances in the air of the working area: guidelines: methodological recommendations МR 118-00-10-2000. Minsk; 2010 (in Russian).

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Sychik S.I., Vasilkevich V.M., Bogdanov R.V., Bondarenko L.M., Bujnickaja A.V.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 81728 от 11 декабря 2013.