CHRONIC INTOXICATION WITH ETHANOL: METABOLIC CHANGES, CORRECTION OF DISTURBANCES

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Abstract

In experimental animals with 30-day and to a greater extent 60-day ethanol intoxication, the development of toxic lesion of the liver, «oxidative stress», disturbances of functional and metabolic activity of erythrocytes and neutrophils in peripheral blood was established. The application of a combination of immune modulator (longidaza), antioxidant (mexicor) and membrane protector (essentiale forte H) completely corrects metabolic disturbances at 30-day ethanol intoxication and partially at 60-day ethanol intoxication.

About the authors

Aleksandr Ivanovich Konoplya

Kursk State Medical University, Ministry of Health of the Russian Federation

Author for correspondence.
Email: noemail@neicon.ru

Доктор мед. наук, проф., заслуженный деятель науки РФ, зав. кафедрой биологической химии Курского государственного медицинского университета Министерства здравоохранения Российской Федерации, 305041, г. Курск, Российская Федерация

e-mail: konoplya51@mail.ru

Russian Federation

Alexey Leonidovich Loktionov

Kursk State Medical University, Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Доктор мед. наук, доц. кафедры хирургических болезней №2 Курского государственного медицинского университета Министерства здравоохранения Российской Федерации, 305041, г. Курск, Российская Федерация

e-mail: ala-loc@yandex.ru

Russian Federation

Valentin Viktorovich Dudka

Kursk State Medical University, Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Ассистент кафедры фармакологии Курского государственного медицинского университета Министерства здравоохранения Российской Федерации, 305041, г. Курск, Российская Федерация

e-mail: dudkaviktor@rambler.ru

Russian Federation

Svetlana Anatolevna Dolgareva

Kursk State Medical University, Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Доктор мед. наук, проф. кафедры биологической химии Курского государственного медицинского университета Министерства здравоохранения Российской Федерации, 305041, г. Курск, Российская Федерация

e-mail: ala-loc@yandex.ru

Russian Federation

Aleksandr Vladimirovich Sorokin

Kursk State Medical University, Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Студент 6 курса лечебного факультета Курского государственного медицинского университета Министерства здравоохранения Российской Федерации, 305041, г. Курск, Российская Федерация

 e-mail: vfts@mail.ru

Russian Federation

Olga Nikolaevna Bushmina

Kursk State Medical University, Ministry of Health of the Russian Federation

Email: noemail@neicon.ru

Ассистент кафедры биологической химии Курского государственного медицинского университета Министерства здравоохранения Российской Федерации, 305041, г. Курск, Российская Федерация

e-mail: bushminaon@kursksmu.net

Russian Federation

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Copyright (c) 2015 Konoplya A.I., Loktionov A.L., Dudka V.V., Dolgareva S.A., Sorokin A.V., Bushmina O.N.


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