Determination of the Microelement Composition of Biopsy Material of Red Bone Marrow in Patients with Hemoblastoses by the SR–XRF Method
- Authors: Trunova V.A.1,2, Pospelova T.I.3, Voytko M.S.3, Krupovich E.S.1,4, Soldatova G.S.3,2, Kuzmin R.O.3, Tsigulyov K.S.3
-
Affiliations:
- Nikolaev Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences
- Novosibirsk State University
- Novosibirsk State Medical University
- Institute of Catalysis of the Siberian Branch of the Russian Academy of Sciences
- Issue: No 2 (2025)
- Pages: 124-130
- Section: Articles
- URL: https://rjonco.com/1028-0960/article/view/686840
- DOI: https://doi.org/10.31857/S1028096025020154
- EDN: https://elibrary.ru/EILIRG
- ID: 686840
Cite item
Abstract
Personalized medicine is a modern concept aimed at individualization of patient therapy. The relevance of the search and identification of new highly sensitive and specific prognostic markers in patients with hemoblastoses is due to the leading positions in the incidence and mortality rate among young working-age population, which gives the problem special socio-economic significance. The study is aimed at studying the content of trace elements in biopsy material (red bone marrow) of patients with hemoblastoses at the onset of the disease and after chemoradiation therapy. Using the method of X-ray fluorescence analysis and synchrotron radiation, it is possible to simultaneously determine more than 25 chemical elements in a low-mass sample with non-destructive sample preparation. Difference in the concentrations of 10 elements (S, K, Ca, Cu, Zn, Fe, Se, Br, Rb, Cd) in patients with two pathologies, lymphoma and leukemia, is considered.
Full Text

About the authors
V. A. Trunova
Nikolaev Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Author for correspondence.
Email: valna-t@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
T. I. Pospelova
Novosibirsk State Medical University
Email: valna-t@mail.ru
Russian Federation, Novosibirsk
M. S. Voytko
Novosibirsk State Medical University
Email: valna-t@mail.ru
Russian Federation, Novosibirsk
E. S. Krupovich
Nikolaev Institute of Inorganic Chemistry of the Siberian Branch of the Russian Academy of Sciences; Institute of Catalysis of the Siberian Branch of the Russian Academy of Sciences
Email: valna-t@mail.ru
Russian Federation, Novosibirsk; Koltsovo
G. S. Soldatova
Novosibirsk State Medical University; Novosibirsk State University
Email: valna-t@mail.ru
Russian Federation, Novosibirsk; Novosibirsk
R. O. Kuzmin
Novosibirsk State Medical University
Email: valna-t@mail.ru
Russian Federation, Novosibirsk
K. S. Tsigulyov
Novosibirsk State Medical University
Email: valna-t@mail.ru
Russian Federation, Novosibirsk
References
- Овечкина В.Н., Бондаренко С.Н., Морозова Е.В. и др. // Клиническая онкогематология. 2017. T. 10 № 3. C. 351. http://doi/org/10.21320/2500-2139-2017-10-3-351-357
- Schmid C., Labopin M., Nagler A., Niederwieser D., Castagna L., Tabrizi R., Stadler M., Kuball J., Cornelissen J., Vorlicek J., Socié G., Falda M., Vindeløv L., Ljungman P., Jackson G., Kröger N., Rank A., Polge E., Rocha V., Mohty M. // Blood. 2012. V. 119. № 6. P. 1599. http://doi/org/10.1182/blood-2011-08-375840
- Christopeit M., Kuss O., Finke J. et al. // J. Clin. Oncol. 2010. V. 31. № 26. P. 3259. http://doi/org/10.1200/JCO.2012.44.7961
- Kröger N., Bornhäuser M., Stelljes M., Pichlmeier U., Trenschel R., Schmid C., Arnold R., Martin H., Heinzelmann M., Wolschke C., Meyer R. G., Bethge W., Kobbe G., Ayuk F., Gökbuget N., Hölzer D., Zander A., Beelen D. // Bone Marrow Transplant. 2014. V. 50. № 12. P. 1503. http://doi/org/10.1038/bmt.2015.202
- Каприн А.Д., Старинский А.В., Шахзадовой А.О. Состояние онкологической помощи населению России в 2022 году. М.: МНИОИ им. П.А. Герцена, 2022. 239 с.
- Мирзаахмедова И.З. // Экономика и социум. 2022. Т. 3. № 2. С. 94.
- Мамедова А.А., Мочкин Н.Е., Саржевский В.О. и др. // Онкогематология. 2022. Т. 17. № 3. С. 40. http://doi/org/10.17650/1818-8346-2022-17-3-40-47
- Савченко В.Г., Паровичникова Е.Н., Афанасьев Б.В. // Гематология и трансфузиология. 2018. Т. 63. № 1-S2. С. 5.
- Azin F., Raie R.M., Mahmoudi M.M. // Ecotoxicology and Environmental Safety. 1998. V. 39. № 3. P. 179.
- Guidotti T.L., McNamara J., Moses M.S. // Indian J. Med. Res. 2008. V. 128. № 4. P. 524.
- Cui Y., Vogt S., Olson N., Glass A.G., Rohan T.E. // Cancer Epidemiol. Biomarkers Prevention. 2007. V. 16. № 8. P. 1682.
- Yelinova V., Glazachev Y., Khramtsov V., Kudryashova L., Rykova V., Salganik R. // Biochem. Biophys. Res. Commun. 1996. V. 221. № 2. P. 300.
- Ohanian M., Telouk P., Kornblau S., Albarede F., Ruvolo Peter, Tidwell R.S., Plesa A., Kangal-Shamanna R., Matera E., Cortes J., Carson A., Dumontet Ch. // Am. J. Hematology. 2020. V. 95. № 4. P. 422. http://doi/org/10.1002/ajh.25731
- Kul A. N., Ozturk Kurt B. // Clinical and Experimental Medicine. 2024. V. 24. № 1. P. 1. http://doi/org/10.1007/s10238-024-01349-5
- Qayyum M.A., Shah M.H. // Biol. Trace Elem. Res. 2020. V. 194. № 1. P. 34. http://doi/org/10.1007/s12011-019-01746-y
- Hasegawa T., InagakI K., Haraguchi H. // Analyt. Sci. 2001. V. 17. P. 979.
- Cirovic A., Cirovic A. // Leukemia Res. 2022. V. 112. Р. 106755. http://doi/org/10.1016/j.leukres.2021.106755
- Ehudin M.A., Golla U., Trivedi D., Potlakayala S.D., Rudrabhatla S.V., Desai D., Dovat S., Claxton D., Sharma A. // Int. J. Mol. Sci. 2022. V. 23. Р. 7972. http://doi/org/10.3390/ijms23147972
- Chrysochou E., Koukoulakis K., Kanellopoulos P.G., Sakellari A., Karavoltsos S., Dassenakis M., Minaidis M., Maropoulos G., Bakeas E. // J. Trace Elements Medicine Biol. 2021. V. 68. Р. 126833. http://doi/org/10.1016/j.jtemb.2021.126833
- Schmitt Y., Schneider H. // Nephrology Dialysis Transplantation. 1993. V. 8. № 5. P. 438.
Supplementary files
