Lechenie sinovial'noy sarkomy u detey

Full Text

Abstract

The results of treatment are analyzed in 48 patients (22 boys and 26 girls; mean age 10.5±3.7 years) with synovial sarcoma at various sites. The patients were divided into 2 groups matched for gender, age, the site and extent of the process, TNM stage, and a history of recurrences. These were a study group (n = 19) and a control one (n = 29). All the patients received multimodality treatment. The study group was treated by the regimen: multidrug therapy (vepesid, cyclophosphanum, and carboplatin as 4 to 8 courses; radiotherapy to a primary focus in a cumulative focal dose (CFD) of 45-50 Gy; if indicated, large-field radiation of the lung in a CFD of 12 Gy; organ-sparing surgery. Subtransplantation doses of autologous peripheral blood stem cells were reinfused in all the patients. In the study group patients, 2-year overall and relapse-free survival rates were 75.6±10.6 and 66.1±11.3%, respectively.

References

  1. Долгополов И С., Янкелевич М. Я. и др. // Педиатрия. - 1999. - № 3. - С. 126-131.
  2. Долгополов И. С., Янкелевич М. Я., Андреева Л. Ю. и др. // Педиатрия. - 1999. - № 3. - С. 58-65.
  3. Менткевич Г. Л. // По материалам Всероссийской науч.-практ. конф. с международным участием "Проблемы трансплантации костного мозга и стволовых клеток периферической крови". - М., 1999. - С. 124-125.
  4. Brecht I. B., Ferrari A. et al. // Pediatr. Blood Cancer. - 2006. - Vol. 46, N 1. - P. 11-17.
  5. Casali P. G., Jost L., Sleijfer S. et al. // Ann. Oncol. - 2008. - Vol. 19. - Suppl. 2. - P. ii89-ii93.
  6. Casanova M., Meazza C. et al. // J. Child Orthop. - 2007. - Vol. 1, N 3. - P. 195-203.
  7. Eilber F. C., Brennan M. F., Eilber F. R. et al. // Ann. Surg. - 2007. - Vol. 246. - P. 105-113.
  8. Ferrari A., Casanova M. et al. // Med. Pediatr. Oncol. - 1999. - Vol. 32, N 1. - P. 32-37.
  9. Ferrari A., Gronchi A., Casanova M. et al. // Cancer. - 2004. - Vol. 101. - P. 627-634.
  10. Gofman A., Issakov J. et al. // Oncol. Rep. - 2007. - Vol. 18, N 6. - P. 1577-1581.
  11. Guadagnolo B. A., Zagars G. K. et al. // Int. J. Radiat. Oncol. Biol. Phys. - 2007. - Vol. 69, N 4. - P. 1173-1180.
  12. Hasegawa T., Yamamoto S., Yokoyama R. et al. // Cancer. - 2002. - Vol. 95. - P. 843-851.
  13. Hawkins D., Felgenhauer J. et al. // Cancer. - 2002. - Vol. 95, N 6. - P. 1356-1365.
  14. Kilpatrick S. E., Bergman S. et al. // Mod. Pathol. - 2006. - Vol. 19. - P. 815-819.
  15. Ladenstein R., Treunr J. et al. // Cancer. - 1993. - Vol. 71. - P. 3647-3655.
  16. Lewis J. J., Antonescu C. R. et al. // J. Clin. Oncol. - 2000. - Vol. 18, N 10. - P. 2087-2094.
  17. Miser J. S., Pappo A. S., Triche T. J. et al. // Principles and Practice of Pediatric Oncology / Eds P. A. Pizzo, D. G. Poplack. - Philadelphia, 2002. - P. 1017-1050.
  18. Okcu M. F., Despa S. et al. // Med. Pediatr. Oncol. - 2001. - Vol. 37, N 2. - P. 90-96.
  19. Okcu M. F., Munsell M. et al. // J. Clin. Oncol. - 2003. - Vol. 21, N 8. - P. 1602-1611.
  20. Palmerini E., Staals E. L. et al. // Cancer. - 2009. - Vol. 115, N 13. - P. 2988-2998.
  21. Pisters P. W., O'Sullivan B., Maki R. G. // J. Clin. Oncol. - 2007. -Vol. 25. - P. 1003-1008.
  22. Ulmer C., Kettelhack C. et al. // Chirurg. - 2003. - Bd 74, N 4. - S. 370-374.
  23. Weiss S. W., Goldblum J. // Soft Tissue Tumors / Eds S. W. Weiss, J. R. Goldblum. - St. Louis, 2001. - P. 1483-1571.

Copyright (c) 2010 Eco-Vector



This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies