Prognozirovanie rezul'tatov lecheniya bol'nykh kolorektal'nym rakom s mnozhestvennymi metastazami v pecheni

Colon cancer is one of the most common malignancies, which annually afflicts as high as 1 million people worldwide. In 20% of patients with colon cancer, its distant metastases primarily to the liver are detectable at diagnosis; metastases develop in the course of the disease in 50%, which become a cause of their death. Expression of p53 in relation to the morphological characteristics of the primary colon tumor spreading to the liver is one of the negative predictors of the course of the tumor process in colorectal cancer that worsens the prognosis of the disease and greatly affects the efficiency of used chemotherapy regimens. The chemotherapy regimen FOLFI-RE overcomes drug resistance in tumor cells, which further permits a positive treatment response to be achieved in most patients.

colon cancer, liver metastases, mutant p53 protein, p53 expression