Aktivnost' proteasom i soderzhanie rostovykh faktorov pri rake pochki, mochevogo puzyrya i endometriya

The proteasome system has been ascertained to play a key role in the development of cancer of the kidney, urinary bladder, and endometrium, which is likely to be linked to the regulation of tissue growth factor levels. Decreased proteasome activity in a renal tissue tumor versus normal tissue is accompanied by activated neoangiogenesis, as suggested by the higher content of vascular endothelial growth factor. In bladder cancer, the activity of tumor enzymes did not differ from their activity in the adjacent tissue. In endometrial cancer tissue, that of proteasome was increased as compared with that in the normal tissue. The content of insulin-like growth factor 1 in the endometrial cancer tissue was associated with the activity of proteasome in the normal tissue.

proteasome activity, vascular endothelial growth factor, insulin-like growth factor 1, renal cancer, bladder cancer, endometrial cancer