Abnormal methylation of the CDH1, RASSF1A, MLH1, N33, and DAPK genes in the tumor and morphologically intact (nontumor) gastric epithelium
- Authors: Nemtsova MV1, Babayan AV1, Bykov II1, Mayorova MV1, Khorobrykh TV1, Chernousov AF1, Zaletaev DV1, Nemtsova MV1, Babayan AV1, Bykov II1, Maiorova MV1, Khorobrykh TV1, Chernousov AF1, Zaletayev DV1
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Affiliations:
- Issue: Vol 16, No 5 (2011)
- Pages: 21-25
- Section: Articles
- URL: https://rjonco.com/1028-9984/article/view/39887
- DOI: https://doi.org/10.17816/onco39887
- ID: 39887
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Abstract
The N33 and CDH1 genes were methylated in the tumor significantly more frequently than were the RASSF1A and MLH1 genes (p < 0.01). Abnormal methylation of the N33, CDH1, and DAPK genes were more often detectable in all gastric tissue segments (1, 2, 3, 4), including morphologically intact tissue with the upper and lower resection margins. The RASSF1A and MLH1 genes had low methylation rates (19 and 17%, respectively). Their methylation was found mainly in the tumor samples (2, 2e) and was not in the samples obtained from the resection margin.
About the authors
M V Nemtsova
Email: nemtsova _m_v@mail.ru
A V Babayan
Email: zalmen@mail.ru
I I Bykov
M V Mayorova
T V Khorobrykh
A F Chernousov
D V Zaletaev
M V Nemtsova
A V Babayan
I I Bykov
M V Maiorova
T V Khorobrykh
A F Chernousov
D V Zaletayev
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