Email this article CLINICOMORPHOLOGICAL QUANTITY PARALELLS OF THE ARGIROPHILIC PROTEINS OF NUCLEOLAR ORGANIZERS REGIONS IN ADENOCARCINOMA OF THE LUNG
- Authors: Kobyakov D.S1, Klimachev V.V2, Avdalyan A.M3, Bobrov I.P3, Bychkova E.Y.3
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Affiliations:
- Municipal health center"Kogalymskaya Hospital"
- The Altay state of medical university
- Altay branch of N.N.Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences
- Issue: Vol 18, No 1 (2013)
- Pages: 28-32
- Section: Articles
- URL: https://rjonco.com/1028-9984/article/view/39960
- DOI: https://doi.org/10.17816/onco39960
- ID: 39960
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Abstract
The argirophilic proteins associated with nucleolar organizers areas (Ag-NOR) in adenocarcinomas of a lung were investigated. Coloring with nitrate silver was carried out according to the standardized protocol. Ag-NOR index area and variation coefficient were defined by the computer analysis of images. Statistically significant differences of Ag-NOR Square index for groups of indicators of T (only for T1), N, primary node 3 cm in size and more, disease stages (only for the I stage) and a tumor differentiation (only for high-differentiated) are received. The variation coefficient of Ag-NOR was statistically significant at differentiation of tumors up to 3 cm and more in high-differentiated moderated and low-differentiated adenocarcinomas. Coefficient determination of Ag-NOR protein variation is less significant in comparison with Ag-NOR Square by comparison of these data to morphological parameters of lung adenocarcinomas.
Full Text
Клинико-морфологические параллели количества аргирофильных белков районов ядрышковых организаторов при аденокарциноме легкого×
About the authors
D. S Kobyakov
Municipal health center"Kogalymskaya Hospital"
Email: dskob@yandex.ru
628481, Kogalym, Russian Federation
V. V Klimachev
The Altay state of medical university656038, Barnaul, Russian Federation
A. M Avdalyan
Altay branch of N.N.Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences656049, Barnaul, Russian Federation
I. P Bobrov
Altay branch of N.N.Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences656049, Barnaul, Russian Federation
E. Yu Bychkova
Altay branch of N.N.Blokhin Russian Cancer Research Center under the Russian Academy of Medical Sciences656049, Barnaul, Russian Federation
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