Email this article Targeted therapy in the treatment of HER-2 positive breast cancer with brain metastases
- Authors: Naskhletashvili D.R.1, Roshchina K.E.1, Gorbunova V.A.1, Gasparyan T.G.1, Bychkov M.B.1, Bekyashev A.H.1, Karakhan V.B.1, Moskvina E.A.1, Aleshin V.A.1, Belov D.M.1, Mitrofanov A.A.1, Prozorenko E.V.1, Pogosova A.A.1
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Affiliations:
- National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
- Issue: Vol 25, No 4 (2020)
- Pages: 146-153
- Section: Clinical investigations
- URL: https://rjonco.com/1028-9984/article/view/59340
- DOI: https://doi.org/10.17816/1028-9984-2020-25-4-146-153
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Abstract
Metastatic damage to the brain is a frequent manifestation in tumors of various localizations, including breast cancer. Until recently, systemic therapy of metastatic brain damage was of limited use; however, with the advent of targeted drugs that are better understood in terms of the specific molecular targets and biological characteristics of metastases, it is now possible to improve treatment results. In an analysis of the results of studies on the problem of metastasis of breast cancer in the brain, a comparison of the use of various targeted drugs in the treatment of metastatic HER2 + breast cancer is presented. The results of a comparison of the degrees of effectiveness of targeted drugs, both in monotherapy and in combination with chemotherapy, were obtained and analyzed.
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About the authors
David R. Naskhletashvili
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Author for correspondence.
Email: nas-david@yandex.ru
ORCID iD: 0000-0002-4218-9652
MD, PhD, senior researcher, N.N. Blokhin National Medical Research Center of Oncology
Russian Federation, MoscowK. E. Roshchina
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
ORCID iD: 0000-0002-6792-967X
Russian Federation
V. A. Gorbunova
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
Russian Federation
T. G. Gasparyan
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
ORCID iD: 0000-0003-0194-7645
Russian Federation
M. B. Bychkov
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
Russian Federation
A. H. Bekyashev
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
ORCID iD: 0000-0002-4160-9598
Russian Federation
V. B. Karakhan
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
ORCID iD: 0000-0001-6325-716X
Russian Federation
E. A. Moskvina
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
Russian Federation
V. A. Aleshin
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
ORCID iD: 0000-0003-1850-5595
Russian Federation
D. M. Belov
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
ORCID iD: 0000-0003-1766-0032
Russian Federation
A. A. Mitrofanov
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
ORCID iD: 0000-0002-4125-7342
Russian Federation
E. V. Prozorenko
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
ORCID iD: 0000-0001-8880-1758
Russian Federation
A. A. Pogosova
National Medical Research Center of Oncology by N.N. Blokhin of the Ministry of Health of Russia
Email: nas-david@yandex.ru
Russian Federation
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