Email this article Роль нейтрофилов опухолевого микроокружения в прогрессии люминального HER2-негативного раннего рака молочной железы
- Authors: Zakurdaev E.1, Bagateliya Z.A.2
-
Affiliations:
- Botkin Hospital
- ГКБ им. С.П. Боткина
- Section: Original Study Articles
- URL: https://rjonco.com/1028-9984/article/view/624111
- DOI: https://doi.org/10.17816/onco624111
- ID: 624111
Cite item
Full Text
Open Access
Access granted
Subscription or Fee Access
Abstract
Background. Luminal Her2-negative breast cancers is the most common type of tumor in women diagnosed with early-stage breast cancer. Stromal cells and immune cells in tumor microenvironment have been reported to have significant value in prognosis of cancers. The prognostic role of tumor-associated neutrophils in early breast cancer remains mostly unclear.
Materials. The dataset consisted of 60 patients with early luminal HER2-negative breast cancer treated in Botkin Hospital. We first estimated basic morphological signs: tumor size, tumor grade by Nottingham Score, tumor-infiltrating lymphocytes, lymphovascular invasion, hormonal receptors status, proliferative index, regional lymph nodes status. The expressions of intratumoral CD15-neutrophyls was studied using immunohistochemistry.
Results. High tumor-associated neutrophils concentration was correlated with tumor size, high grade tumors, proliferative index, tumor-infiltrating lymphocytes, lymphovascular invasion and positive regional lymph nodes.
Conclusions: Tumor-associated neutrophils predicted a worse prognosis in early luminal Her2-negative breast cancer.
Full Text
About the authors
Evgenii Zakurdaev
Botkin Hospital
Author for correspondence.
Email: ezakurdaev@yandex.ru
ORCID iD: 0000-0001-8613-9609
pathologist
Russian FederationZurab Antonovich Bagateliya
ГКБ им. С.П. Боткина
Email: ezakurdaev@yandex.ru
ORCID iD: 0000-0001-5699-3695
SPIN-code: 5391-5670
References
- Breast cancer. Clinical recommendations. 2021. url: https://cr.minzdrav.gov.ru/schema/379_4 (In Russ)
- Grassadonia A., Graziano V., Iezzi L., Vici P. et. al. Prognostic Relevance of Neutrophil to Lymphocyte Ratio (NLR) in Luminal Breast Cancer: A Retrospective Analysis in the Neoadjuvant Setting. Cells. 2021;10(7):1685. doi: 10.3390/cells10071685.
- Criscitiello C., Vingiani A., Maisonneuve P., Viale G. Tumor-infiltrating lymphocytes (TILs) in ER+/HER2-breast cancer. Breast Cancer Res Treat. 2020;183(2):347-354. doi: 10.1007/s10549-020-05771-7.
- Okcu O., Öztürk S.D., Öztürk Ç., Şen B., Yasin A.İ., Bedir R. Tumor-infiltrating lymphocytes (TILs)/volume and prognosis: The value of TILs for survival in HER2 and TN breast cancer patients treated with chemotherapy. Ann Diagn Pathol. 2022;58:151930. doi: 10.1016/j.anndiagpath.2022.151930.
- Pawelczyk K., Piotrowska A., Ciesielska U., Jablonska K. et al. Role of PD-L1 Expression in Non-Small Cell Lung Cancer and Their Prognostic Significance according to Clinicopathological Factors and Diagnostic Markers. Int J Mol Sci. 2019;20(4):824. doi: 10.3390/ijms20040824.
- Soto-Perez-de-Celis E., Chavarri-Guerra Y., Leon-Rodriguez E., Gamboa-Dominguez A. Tumor-Associated Neutrophils in Breast Cancer Subtypes. Asian Pac J Cancer Prev. 2017;18(10):2689-2693. doi: 10.22034/APJCP.2017.18.10.2689.
- Wang Y., Zhai J., Zhang T., Han S. et al. Tumor-Associated Neutrophils Can Predict Lymph Node Metastasis in Early Gastric Cancer. Front Oncol. 2020;10:570113. doi: 10.3389/fonc.2020.570113.
- Ji F., Kang Q., Wang L., Liu L. et al. Prognostic significance of the neutrophil-to-lymphocyte ratio with distal cholangiocarcinoma patients. Medicine (Baltimore). 2020;99(43):e22827. doi: 10.1097/MD.0000000000022827.
- Geng S.K., Fu S.M., Ma S.H., Fu Y.P., Zhang H.W. Tumor infiltrating neutrophil might play a major role in predicting the clinical outcome of breast cancer patients treated with neoadjuvant chemotherapy. BMC Cancer. 2021;21(1):68. doi: 10.1186/s12885-021-07789-6.
Supplementary files
