THE SEARCH FOR NOVEL ANTICANCER AGENTS BASED ON STRUCTURAL MODIFICATION OF STEROIDOGENESIS ENZYME INHIBITORS

The review is devoted to the results of studies of new inhibitors of the main enzymes of steroidogenesis from the point of view of their use as antitumor agents. The review consists of 3 chapters, each of which is devoted to the optimization of the structures of synthetic inhibitors of key enzymes of steroidogenesis - 5α-reductase, 17β-hydroxysteroid dehydrogenase (17β-HSD) and 17α-hydroxylase-17/20-lyase (CYP17A1). The structures of 209 new steroid inhibitors are presented, and the biological effects for these compounds that lie outside the biosynthesis of steroids are described. Analysis of the cited literature allows us to consider steroid inhibitors of these enzymes as antitumor agents with high pharmacological potential, and optimization of their structures as a convenient tool for searching for new compounds with an optimal ratio of effectiveness and number of side effects.