Magnetic nanodisks for therapy of malignant neoplasms



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Abstract

Persistent increase in cancer incidence, contributing to substantial mortality and disability rates among the working-age population, underscores the importance of developing innovative therapeutic approaches. Researchers are particularly interested in the promising field of magnetically controlled microsurgery of individual tumor cells, which utilizes functionalized magnetic nanostructures. Among various types of magnetic particles, nanodiscs exhibit the greatest potential due to their unique magnetic properties. Their modification with targeting molecules enables the creation of highly specific systems for precise tumor cell intervention. This review evaluates the prospects of using functionalized magnetic nanodiscs (“smart nanoscalpels”) for the selective destruction of malignant cells. The study involved a systematic analysis of scientific literature (2022–2025) from the PubMed database, using the following key terms: “magnetic nanodiscs”, “malignant neoplasms”, “magnetic nanoparticles”. Special focus was given to studying the operational principles of a nanodisks capable of selectively destroying tumor cells under an alternating magnetic field while preserving the viability of surrounding healthy tissues. The conducted analysis demonstrates the substantial potential of targeted magnetic nanodiscs as a promising adjuvant tool for: selective elimination of residual tumor cells in the postoperative perio; treatment of disseminated metastatic lesions; however, translating the magnetomechanical approach from experimental research to clinical practice requires comprehensive preclinical testing, including optimization of nanodisc physicochemical parameters, rigorous evaluation of efficacy and safety, development of standardized application protocols.

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About the authors

Victoria D. Fedotovskaya

Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia; Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia

Email: viktoriia.fedotovskaia@gmail.com
ORCID iD: 0000-0002-6472-0782
SPIN-code: 4500-4728
Russian Federation, Krasnoyarsk, Russia; Krasnoyarsk, Russia

Tatiana N. Zamay

Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia; Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia

Email: tzamay@yandex.ru
ORCID iD: 0000-0002-7493-8742
SPIN-code: 8799-8497

Dr. Sci. (Biology)

Russian Federation, Krasnoyarsk, Russia; Krasnoyarsk, Russia

Olga S. Kolovskaya

Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia; Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia

Email: olga.kolovskaya@gmail.com
ORCID iD: 0000-0002-2494-2313
SPIN-code: 2254-5474

Dr. Sci. (Biology)

Russian Federation, Krasnoyarsk, Russia; Krasnoyarsk, Russia

Anna S. Kichkailo

Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia; Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia

Email: annazamay@yandex.ru
ORCID iD: 0000-0003-1054-4629
SPIN-code: 2217-2229

Dr. Sci. (Biology)

Russian Federation, Krasnoyarsk, Russia; Krasnoyarsk, Russia

Rinat G. Galeev

NPP «Radiosviaz», Krasnoyarsk, Russia

Email: info@krtz.su

Dr. Sci. (Physics and Mathematics)

Russian Federation, Krasnoyarsk, Russia

Ruslan A. Zukov

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia; Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I. Kryzhanovsky, Krasnoyarsk, Russia

Email: zukov.ra@krasgmu.ru
ORCID iD: 0000-0002-7210-3020
SPIN-code: 3632-8415
Russian Federation, Krasnoyarsk, Russia; Krasnoyarsk, Russia

Sergey G. Ovchinnikov

L.V. Kirensky Institute of Physics, Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia

Email: sgo@iph.krasn.ru
ORCID iD: 0000-0003-1209-545X
SPIN-code: 4857-6804

Dr. Sci. (Physics and Mathematics)

Russian Federation, Krasnoyarsk, Russia

Sergey S. Zamay

Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences, Krasnoyarsk, Russia

Author for correspondence.
Email: sergey-zamay@yandex.ru
ORCID iD: 0000-0002-4828-7077
SPIN-code: 6227-2236

Cand. Sci. (Physics and Mathematics)

Russian Federation, Krasnoyarsk, Russia

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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