Role of ultrastaging in sentinel lymph node biopsy with ICG mapping in endometrial cancer



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BACKGROUND: Endometrial cancer is oncological disease of the female reproductive system in developed countries, typically detected at early stages. Currently, one of the most popular methods for sentinel lymph node mapping and biopsy in stage I endometrial cancer is the use of indocyanine green (ICG) followed by ultrastaging technology.

AIM: To determine the feasibility and protocol of sentinel lymph node ultrastaging following ICG mapping in different risk groups for lymphogenic metastases in stage I endometrial cancer.

MATERIALS AND METHODS: A cohort study was conducted, including 286 patients with verified uterine body cancer at stages cT1a-T1bN0M0, who underwent treatment at the Department of Oncogynecology No. 70 of the Moscow S.P. Botkin Multidisciplinary Research and Clinical Center of the Moscow Department of Health and at the Kaluga Regional Clinical Oncology Center from 2023 to 2024. Patients underwent sentinel lymph node biopsy (SLNB) with ICG mapping using indocyanine green and subsequent ultrastaging.

RESULTS: The bilateral detection rate of sentinel lymph nodes was 70.9%. The detection rate of N1 in the low-risk group was 3.6%, in the intermediate-risk group — 12.8%, and in the high-risk group — 21.3%. A trend toward an increase in the proportion of macrometastases was observed as the risk increased from low to high. The proportion of metastatic changes detected through immunohistochemical (IHC) examination was 28.3%.

CONCLUSION: SLNB is advisable in all risk groups for lymphogenic metastasis, except for patients with high risk, who, according to the new FIGO 2023 classification of endometrial cancer, will be classified as stage II of the disease. This cohort of patients is recommended to undergo full lymphadenectomy.

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作者简介

Vladimir Alimov

Moscow S.P. Botkin Multidisciplinary Research and Clinical Center, Moscow, Russia; Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Email: alimovvladimirr@gmail.com
ORCID iD: 0000-0002-6423-3917
SPIN 代码: 6262-0720

MD, Cand. Sci. (Medicine), researcher, head of gynecological oncology department 

俄罗斯联邦, Moscow, Russia; Moscow, Russia

Sergei Skugarev

Kaluga Regional Clinical Oncology Center, Kaluga, Russia

Email: skugarevsa@gmail.com
ORCID iD: 0000-0002-0521-8207
SPIN 代码: 5682-7051

surgeon, oncologist, gynaecologist, head of the department of oncogynaecology and breast tumours, Kaluga Regional Clinical Oncological Dispensary, Kaluga Region

俄罗斯联邦, Kaluga, Russia

Elena Novikova

Hertsen Moscow Oncology Research Institute — branch of the National Medical Research Radiological Centre, Moscow, Russia

Email: egnov@bk.ru
ORCID iD: 0000-0003-2768-5698
SPIN 代码: 2143-9975

MD, Dr. Sci. (Medicine), Professor, Honoured Scientist of the Russian Federation, Honoured Physician of Russia, Laureate of the State Prize of the Russian Federation

俄罗斯联邦, Moscow, Russia

Sergei Lebedev

Moscow S.P. Botkin Multidisciplinary Research and Clinical Center, Moscow, Russia; Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Email: lebedevssd@yandex.ru
ORCID iD: 0000-0001-5366-1281
SPIN 代码: 2736-0683

MD, Cand. Sci. (Medicine), surgeon, oncologist, leading researcher

俄罗斯联邦, Moscow, Russia; Moscow, Russia

Zurab Bagatelia

Moscow S.P. Botkin Multidisciplinary Research and Clinical Center, Moscow, Russia; Russian Medical Academy of Continuous Professional Education, Moscow, Russia

Email: bagateliaza@botkinmoscow.ru
ORCID iD: 0000-0001-5699-3695
SPIN 代码: 5391-5670

MD, Dr. Sci. (Medicine), Professor, surgeon, oncologist, leading researcher

俄罗斯联邦, Moscow, Russia; Moscow, Russia

Anastasia Laevskaya

Moscow S.P. Botkin Multidisciplinary Research and Clinical Center, Moscow, Russia

Email: ayaksveal@yandex.ru
ORCID iD: 0000-0002-5593-6549
俄罗斯联邦, Moscow, Russia

Anna Arutyunyan

Moscow S.P. Botkin Multidisciplinary Research and Clinical Center, Moscow, Russia

Email: dr.arutyunyana@gmail.com

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Moscow, Russia

Dmitriy Lantsov

Kaluga Regional Clinical Oncology Center, Kaluga, Russia

Email: alimovvladimirr@gmail.com
ORCID iD: 0009-0001-7314-4844

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Kaluga, Russia

Irina Tinkova

Moscow S.P. Botkin Multidisciplinary Research and Clinical Center, Moscow, Russia

Email: alimovvladimirr@gmail.com
ORCID iD: 0000-0002-6960-1184

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Moscow, Russia

Alexey Shabunin

Moscow S.P. Botkin Multidisciplinary Research and Clinical Center, Moscow, Russia; Russian Medical Academy of Continuous Professional Education, Moscow, Russia

编辑信件的主要联系方式.
Email: info@botkinmoscow.ru
ORCID iD: 0000-0002-4230-8033
SPIN 代码: 8917-7732

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, Moscow, Russia; Moscow, Russia

参考

  1. Oaknin A, Bosse TJ, Creutzberg CL, et al. Endometrial cancer: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Annals of oncology. 2022;33(9):860–877. doi: 10.1016/j.annonc.2022.05.009
  2. Kuhn TM, Dhanani S, Ahmad S. An overview of endometrial cancer with Novel Therapeutic strategies. Current oncology. 2023;30(9):7904–7919. doi: 10.3390%2Fcurroncol30090574
  3. Baker-Rand H, Kitson SJ. Recent advances in endometrial cancer prevention, early diagnosis and treatment. Cancers. 2024;16(5):1028. doi: 10.3390/cancers16051028
  4. Dick A, Perri T, Kogan L, et al. Sentineal lymph node mapping in endometrial cancer: a comparison of main national and international guidelines. International journal of gynecology and obstetrics. 2022;160(1):220–225. doi: 10.1002/ijgo.14307
  5. Ignatov A, Lebius C, Ignatov T, et al. Lymph node micrometastases and outcome of endometrial cancer. Gynecol. Oncncol. 2019;154(3):475–479. doi: 10.1016/j.ygyno.2019.07.018
  6. Pineda GV, Gutierrez HA, Segovia GM, et al. Low-volume nodal metastasis in endometrial cancer: risk factors and prognostic significance. J Clin Med. 2020;9(6):1999. doi: 10.3390/jcm9061999
  7. Lee JH, Li JJ. Sentinel lymph node mapping in endometrial cancer: an update review. Journal gynaecology and obstetrics midwifery. 2022;22(2):114–124. doi: 10.12809/hkjgom.22.2.08
  8. Multinu F, Casarin J, Cappuccio S, et al. Ultrastaging of negative pelvic lymph nodes to decrease the true prevalence of isolated paraaortic dissemination in endometrial cancer. Gynecologic oncology. 2019;154(1):60–64. doi: 10.1016/j.ygyno.2019.05.008
  9. Pinelli C, Artuso V, Bogani G, et al. Lymph node evaluation in endometrial cancer: how did it change over the last two decades? Translational cancer research. 2020;9(12):7778–7784. doi: 10.21037/tcr-20-2165
  10. Abdelazim IA, Abu-Faza M, Zhurabekova G, et al. Sentinel lymph nodes in endometrial cancer update 2018. Gynecol Minim Invasive Ther. 2019;8:94–100. doi: 10.4103/GMIT.GMIT_130_18
  11. Ibragimov ZN, Mikaya NA, Trifanov YuN, et al. Indocyanine green (ICG) for the detection of sentinel lymph nodes in patients with endometrial cancer. Akusherstvo i ginekologiya. 2020;1_Supple:105–111. doi: 10.18565/aig.2020.1suppl.105-111 EDN: SEGOUV
  12. Khoury-Collado F, Clair CST, Abu-Rustum NR, et al. Sentinel lymph node mapping in endometrial cancer: an update. Oncologist. 2016;21(4):461–466. DOI: https://doi.org/10.1634/theoncologist.2015-0473.
  13. Fan MS, Qiu KX, Wang DY, et al. Risk factors associated with false negative rate of sentinel lymph node biopsy in endometrial cancer: a systematic review and meta-analysis. Front Oncol. 2024;14:1391267. doi: 10.3389/fonc.2024.1391267
  14. How J, Boldeanu I, Lau S, et. al. Unexpected locations of sentinel lymph nodes in endometrial cancer. Gynecol Oncol. 2017;147(1):18–23. doi: 10.1016/j.ygyno.2017.07.125
  15. Kolomiets LA, Chernyshova AL, Chernov VI, et al. Detection of sentinel lymph nodes in patients with gynecological cancer: Video guide for doctors [Electronic edition]. Tomsk: Tomsk National Research Medical Center of the Russian Academy of Sciences; 2022. doi: 10.21294/978-5-6048147-0-3-2022 EDN: VBKYRM
  16. Cabrera S, Bebia V, Franco-Camps S, et al. Technetium-99m-indocyanine green versus technetium-99m-methylene blue for sentinel lymph node biopsy in early-stage endometrial cancer. Int J Gynecol Cancer. 2020;30(3):311–317. doi: 10.1136/ijgc-2019-000923
  17. Rossi EC, Kowalski LD, Scalici J, et al. A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES Trial): a multicentre, prospective cohort study. Lancet oncology. 2017;18(3):384–92. doi: 10.1016/S1470-2045 (17)30068-2
  18. Volchenko NN, Borisova OV, Melnikova VYu, Ermolaeva AG, Glukhova YuK. Urgent intraoperative cytological examination of sentinel lymph nodes in early breast cancer. P.A. Herzen Journal of Oncology. 2019;8(3):169–174. doi: 10.17116/onkolog2019803115169 EDN: NZWTCX
  19. Zhang-Yin J, Mauel E, Talpe S. Update on Sentinel Lymph Node Methods and Pathology in Breast Cancer. Diagnostics. 2024;14:252. doi: 10.3390/diagnostics14030252
  20. Ahuja S, Yadav P, Fattahi-Darghlou M, Zaheer S. Comparison of Intraoperative Imprint Cytology versus Frozen Section for Sentinel Lymph Node Evaluation in Breast Cancer. A study along with Systematic Review and Meta-analysis of literature. Asian Pac J Cancer Prev. 2024;25(4):1113–1119. doi: 10.31557/APJCP.2024.25.4.1113
  21. Chiang S, Tessier-Cloutier B, Klein E, et al. Establishing guidelines for sentinel lymph node ultrastaging in endometrial cancer. Int J Gynecol Cancer. 2024;34(5):681–688. doi: 10.1136/ijgc-2023-005157
  22. Clark C, Loizzi V, Cormio G, Lopez S. Sentinel Lymph Node Assessment in Endometrial Cancer: A Review. Cancers. 2024;16:3202. doi: 10.3390/cancers16183202
  23. Euscher ED, Malpica A. Gynaecological malignancies and sentinel lymph node mapping: an update. Histopathology. 2020;76(1):139–150. doi: 10.1111/his.14017
  24. Burg LC, Hengeveld EM, Hout J, et al. Ultrastaging methods of sentinel lymph nodes in endometrial cancer — a systematic review. Int J Gynecol Cancer. 2021;31:744–753. doi: 10.1136/ijgc-2020-001964
  25. Collins A, Phillips A. Sentinel lymph node mapping in the modern management of gynaecological malignancy. The obstetrics and gynaecologist. 2023;25(3):210–219. doi: 10.1111/tog.12872
  26. Zhai L, Zhang X, Cui M, et al. Sentinel lymph node mapping in endometrial cancer: a comprehensive review. Front Oncol. 2021;11:701758. doi: 10.3389/fonc.2021.701758
  27. Sorokin P, Novozhilov M, Utkin D, et al. Tailoring postoperative management through sentinel lymph node biopsy in low- and intermediate-risk endometrial cancer — the SENTRY clinical trial. Klin Onkol. 2024;37(2):126–133. doi: 10.48095/ccko2024126 EDN: APFVJU
  28. Bendifallash S, Canlorbe G, Laas E, et al. A predictive model using histopathologic characteristics of early-stage type 1 endometrial cancer to identify patients at high risk for lymph node metastasis. Ann Surg Oncol. 2015;22:4224-4232. doi: 10.1245/s10434-015-4548-6
  29. Schwameis R, Fanfani F, Ebner C, et al. Verification of the prognostic precision of the new 2023 FIGO staging system in endometrial cancer patients — An international pooled analysis of three ESGO accredited centres. Eur J Cancer. 2023;193:113317. doi: 10.1016/j.ejca.2023.113317

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