Antimalarial Effects of Nano Chloroquine Loaded Curcumin In vivo


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Abstract

Background:Malaria is still the deadliest parasitic disease caused by Plasmodium spp. Due to drug resistance and their unpleasant side effects, of conventional researchers are enormously seeking to achieve antimalarial drugs with more curative effective, less toxic and cost-affordable drugs using more advanced technology such as nanodrugs

Purpose:The present study aimed to examine the antimalarial effects of a novel synthesized nonochloroquine-loaded curcumin relying on dendrimer G2 in susceptible mice.

Methods:Antimalarial activity and toxicity of the nanocomposite were examined on BALB/C mice with microscopy, checking RBCs morphology and related enzymatic activity rate.

Results:The maximum inhibitory effect of the nanocomposite was seen at 10 mg/kg, killing 98% of P. berghei compared to sole chloroquine, whereas ED50 was reported at 5.5 mg/kg. The safety of the synthesized nanocomposite was confirmed with biochemical tests with no detrimental effects on mice. The sustainability and longevity of the nanodrug increased significantly with the NDC-CQ assay compared to the control groups

Conclusion:The study showed that nonochloroquine-loaded curcumin had a promising inhibitory effect on P. berghei growth in infected mice compared to standard drugs. However, further studies and clinical trials with large samples are recommended to study different aspects of using nanodrug.

About the authors

Taher Elmi

Department of Laboratory Science, School of Medicine, Islamic Azad University

Email: info@benthamscience.net

Fatemeh Tabatabaie

Department of Parasitology and Mycology, School of Medicine, Iran University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

Mehdi Ardestani

Department of Radio Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences

Email: info@benthamscience.net

Abdolhossein Dalimi

Department of Parasitology, Faculty of Medical Sciences,, Tarbiat modares University

Email: info@benthamscience.net

Fatemeh Ghaffarifar

Department of Parasitology, Faculty of Medical Sciences, Tarbiat modares University

Email: info@benthamscience.net

Zahra Zamani

Biochemistry Department, Pasteur Institute of Iran

Email: info@benthamscience.net

Fatemeh Maleki

Department of Parasitology, School of Allied Medical Sciences, Iran University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

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