Formulation and Optimization of Polyherbal Nanogel for Dermatological Applications


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Abstract

Aim:The aim of the present investigation was to develop a polyherbal nano gel (PHNG) formulation capable of acting as a potential vehicle to deliver polyherbal phytoconstituents topically.

Background:Individual herbs, according to Ayurveda, are insufficient to deliver the intended medicinal effect. It will have a better therapeutic impact with less toxicity when it is optimized as multiple herb combinations in a certain ratio.

Objective:The objective of this study was to create a polyherbal gel for the delivery of medication from methanolic extracts of Plumbago zeylanica Linn, Datura stramonium Linn, and Argemone mexicana Linn.

Material and Methods:The plant parts chosen for this work include methanolic extracts of Plumbago zeylanica stem, Datura stramonium leaves, Argimone Mexicana areal part. The polyherbal-based nanogel was prepared by low energy self-emulsification technique, and was evaluated for pH, viscosity and spreadability, stability, and drug release. The drug release profile of stable nanogel formulations was studied at various time intervals. Furthermore, the prepared nanogel was characterized by zeta-potential, zeta-sizer, and transmission electron microscopy (TEM).

Result:Optimized PHNG had particle size and zeta potential of 11.25nm and -25.73 mV respectively. TEM analysis of optimized formulation revealed the spherical shape of particles. Furthermore, the optimized formulation was found to possess higher stability with a maximum extended cumulative release of up to 240 minutes.

Conclusion:We have formulated a polyherbal nanogel that can be validated by physiochemical and surface characterization.

About the authors

Suresh Dev

Pacific College of Pharmacy, Pacific Academy of Higher Education and Research University

Author for correspondence.
Email: info@benthamscience.net

Pratim Choudhury

Department of Pharmaceutical Science, Mohanlal Sukhadia University

Email: info@benthamscience.net

Rajnish Srivastava

Faculty of Pharmacy, Moradabad Educational Trust Group of Institutions

Email: info@benthamscience.net

Vaibhav Rathore

Department of Pharmaceutical Sciences, Mohanlal Sukhadia University

Email: info@benthamscience.net

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