Silver Nanoparticulate Carriers: A Significant Development in Nanotechnology


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Abstract

Background:For centuries, silver has been known for its anti-bacterial effects. It also helps in the prevention and control of various infections. Silver, when synthesized in nano-size, is much more effective, so the trend of using silver nanoparticles in treating mild bacterial diseases to deadly infectious diseases has increased rapidly.

Methods:Silver nanoparticles can be synthesized by physical, chemical, and biological methods. Nanoparticles are developed in different shapes and have a wide range of sizes, with the purpose of controlling the release rate and content of the drug’s dose. The nanoparticles can be administered via oral, pulmonary, dermal, and intravenous routes.

Results:Silver nanoparticles have been used in treating diseases, such as cancers, diabetes, etc., by targeted drug delivery and in cosmetics, wound healing, diagnostics, water purifying, bio-imaging, air purification, etc. The research on the novel applications of silver nanoparticles merits its medical application, and this utility aspect is granting patented technologies. The utilization of silver nanoparticles has enhanced in recent times due to their effectiveness in the specified diseased state.

Conclusion:Studies have indicated that the drugs developed using silver nanoparticles manifest safety as they are biocompatible; thus, silver nanoparticles display a promising role in developing futuristic medical therapeutic strategies.

About the authors

Boga Kumar

Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy

Email: info@benthamscience.net

Gyati Asthana

Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy

Author for correspondence.
Email: info@benthamscience.net

Abhay Asthana

, PharmaSol Group,

Email: info@benthamscience.net

Rakesh Gaddam

Department of Pharmaceutics, Gokaraju Rangaraju College of Pharmacy

Email: info@benthamscience.net

References

  1. Khan I, Saeed K, Khan I. Nanoparticles: Properties, applications and toxicities. Arab J Chem 2019; 12(7): 908-31. doi: 10.1016/j.arabjc.2017.05.011
  2. Babu A, Templeton AK, Munshi A, Ramesh R. Nanoparticle-based drug delivery for therapy of lung cancer: Progress and challenges. J Nanomater 2013; 2013: 1-11. doi: 10.1155/2013/863951
  3. Sim W, Barnard R, Blaskovich MAT, Ziora Z. Antimicrobial Silver in medicinal and consumer applications: A patent review of the past decade (2007–2017). Antibiotics 2018; 7(4): 93. doi: 10.3390/antibiotics7040093 PMID: 30373130
  4. Adebayo IA, Usman AI, Shittu FB, et al. Boswellia dalzielii -Mediated silver nanoparticles inhibited acute myeloid leukemia (AML) Kasumi-1 cells by inducing cell cycle arrest. Bioinorg Chem Appl 2020; 2020: 1-11. doi: 10.1155/2020/8898360 PMID: 33029114
  5. Choudhury H, Pandey M, Lim YQ, et al. Silver nanoparticles: Advanced and promising technology in diabetic wound therapy. Mater Sci Eng C 2020; 112: 110925. doi: 10.1016/j.msec.2020.110925 PMID: 32409075
  6. Yin IX, Zhang J, Zhao IS, Mei ML, Li Q, Chu CH. The antibacterial mechanism of silver nanoparticles and its application in dentistry. Int J Nanomedicine 2020; 15: 2555-62. doi: 10.2147/IJN.S246764 PMID: 32368040
  7. Dung TTN, Nam VN, Nhan TT, et al. Silver nanoparticles as potential antiviral agents against African swine fever virus. Mater Res Express 2019; 6: 250g9.
  8. He Y, Du Z, Ma S, et al. Biosynthesis, antibacterial activity and anticancer effects against Prostate Cancer (PC-3) cells of silver nanoparticles using Dimocarpus Longan Lour. Peel extract. Nanoscale Res Lett 2016; 11(1): 300. doi: 10.1186/s11671-016-1511-9 PMID: 27316741
  9. Zhang XF, Liu ZG, Shen W, Gurunathan S. Silver nanoparticles: Synthesis, characterization, properties, applications, and therapeutic approaches. Int J Mol Sci 2016; 17(9): 1534. doi: 10.3390/ijms17091534 PMID: 27649147
  10. Helmlinger J, Sengstock C, Groß-Heitfeld C, et al. Silver nanoparticles with different size and shape: Equal cytotoxicity, but different antibacterial effects. RSC Advances 2016; 6(22): 18490-501. doi: 10.1039/C5RA27836H
  11. Abbaszadegan A, Ghahramani Y, Gholami A, et al. The effect of charge at the surface of silver nanoparticles on antimicrobial activity against gram-positive and gram-negative bacteria: A preliminary study. J Nanomater 2015; 2015: 1-8. doi: 10.1155/2015/720654
  12. Prodana M, Ionita D, Ungureanu C, Bojin D, Demetrescu I. Enhancing antibacterial effect of multiwalled carbon nanotubes using silver nanoparticles. Dig J Nanomater Biostruct 2011; 6(2): 549-56.
  13. Deivaraj TC, Lala NL, Lee JY. Solvent-induced shape evolution of PVP protected spherical silver nanoparticles into triangular nanoplates and nanorods. J Colloid Interface Sci 2005; 289(2): 402-9. doi: 10.1016/j.jcis.2005.03.076 PMID: 16112224
  14. Rahman S, Rahman L, Khalil AT, et al. Endophyte-mediated synthesis of silver nanoparticles and their biological applications. Appl Microbiol Biotechnol 2019; 103(6): 2551-69. doi: 10.1007/s00253-019-09661-x PMID: 30721330
  15. Prabhu S, Poulose EK. Silver nanoparticles: Mechanism of antimicrobial action, synthesis, medical applications, and toxicity effects. Int Nano Lett 2012; 2(1): 32. doi: 10.1186/2228-5326-2-32
  16. Lee S, Jun BH. Silver nanoparticles: Synthesis and application for nanomedicine. Int J Mol Sci 2019; 20(4): 865. doi: 10.3390/ijms20040865 PMID: 30781560
  17. Habiba K, Makarov VI, Weiner BR, Morell G. Fabrication of Nanomaterials by Pulsed Laser Synthesis. Manufacturing Nanostructures. Manchester, UK: One Central Press 2014; pp. 263-91.
  18. Iravani S, Korbekandi H, Mirmohammadi SV, Zolfaghari B. Synthesis of silver nanoparticles: Chemical, physical and biological methods. Res Pharm Sci 2014; 9(6): 385-406. PMID: 26339255
  19. Prasad Yadav T, Manohar Yadav R, Pratap Singh D. Mechanical milling: A top down approach for the synthesis of nanomaterials and nanocomposites. Nanosci Nanotech 2012; 2(3): 22-48. doi: 10.5923/j.nn.20120203.01
  20. Urban FK III, Hosseini-Tehrani A, Griffiths P, Khabari A, Kim YW, Petrov I. Nanophase films deposited from a high-rate, nanoparticle beam. J Vac Sci Technol B 2002; 20(3): 995-9. doi: 10.1116/1.1481749
  21. Alhamid MZ, Hadi BS, Khumaeni A. Synthesis of silver nanoparticles using laser ablation method utilizing Nd: YAG laser. AIP Conf Proc 2019; 2202(1): 0200131-5.
  22. Swihart MT. Vapor-phase synthesis of nanoparticles. Curr Opin Colloid Interface Sci 2003; 8(1): 127-33. doi: 10.1016/S1359-0294(03)00007-4
  23. Ahmad RM. Preparation methods of silver nanoparticles WIPO (PCT) Patent 2012074355, 2012.
  24. Karandikar BM, Gibbins BL. Methods and compositions for metal nanoparticle treated surfaces U.S. Patent 8361553, 2013.
  25. Awad MAG, Hendi AA, Wagealla MAE, Ortashi KMO, Virk P. Synthesis of nanoparticles of metals and metal oxides using plant seed extract U.S. Patent 9428399, 2016.
  26. Kalishwaralal K, Deepak V, Ramkumarpandian S, Nellaiah H, Sangiliyandi G. Extracellular biosynthesis of silver nanoparticles by the culture supernatant of Bacillus licheniformis. Mater Lett 2008; 62(29): 4411-3. doi: 10.1016/j.matlet.2008.06.051
  27. Kholoud MM, El-Nour A, Eftaiha A, Al-Warthan A, Ammar RAA. Synthesis and applications of silver nanoparticles. Arab J Chem 2009; 3(3): 135-40.
  28. Palama IE, Pollini M, Paladini F, Accorsi G, Sannino A, Gigli G. Cancer therapy with silver nanoparticles WIPO (PCT) Patent 2015015301, 2015.
  29. Guo D, Zhu L, Huang Z, et al. Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions. Biomaterials 2013; 34(32): 7884-94. doi: 10.1016/j.biomaterials.2013.07.015 PMID: 23876760
  30. Guo D, Zhao Y, Zhang Y, et al. The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid leukemia cells. J Biomed Nanotechnol 2014; 10(4): 669-78. doi: 10.1166/jbn.2014.1625 PMID: 24734519
  31. Zhang J, He C, Fei X, Xu T. Anti-Leukemia activity of hyaluronic acid coated silver nanoparticles for selective targeting to leukemic cells. J Biomater Tissue Eng 2018; 8(6): 906-10. doi: 10.1166/jbt.2018.1812
  32. Firdhouse MJ, Lalitha P. Biosynthesis of silver nanoparticles using the extract of Alternanthera sessilis—antiproliferative effect against prostate cancer cells. Cancer Nanotechnol 2013; 4(6): 137-43. doi: 10.1007/s12645-013-0045-4 PMID: 26069509
  33. Zielinska E, Zauszkiewicz-Pawlak A, Wojcik M, Inkielewicz-Stepniak I. Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma. Oncotarget 2018; 9(4): 4675-97. doi: 10.18632/oncotarget.22563 PMID: 29435134
  34. Barcińska E, Wierzbicka J, Zauszkiewicz-Pawlak A, Jacewicz D, Dabrowska A, Inkielewicz-Stepniak I. Role of Oxidative and nitro-oxidative damage in silver nanoparticles cytotoxic effect against human pancreatic ductal adenocarcinoma cells. Oxid Med Cell Longev 2018; 2018: 1-15. doi: 10.1155/2018/8251961 PMID: 30186549
  35. Palaniappan P, Sathishkumar G, Sankar R. Fabrication of nano-silver particles using Cymodocea serrulata and its cytotoxicity effect against human lung cancer A549 cells line. Spectrochim Acta A Mol Biomol Spectrosc 2015; 138: 885-90. doi: 10.1016/j.saa.2014.10.072 PMID: 25467657
  36. Liu J. Anti-cancer nano-silver composition for treatment of lung cancer, and preparation method and use thereof U.S. Patent 20170119818, 2017.
  37. Sharma GN, Dave R, Sanadya J, Sharma P, Sharma KK. Various types and management of breast cancer: An overview. J Adv Pharm Technol Res 2010; 1(2): 109-26. PMID: 22247839
  38. Swanner J, Fahrenholtz CD, Tenvooren I, et al. Silver nanoparticles selectively treat triple-negative breast cancer cells without affecting non-malignant breast epithelial cells in vitro and in vivo. FASEB Bioadv 2019; 1(10): 639-60. doi: 10.1096/fba.2019-00021 PMID: 32123812
  39. Gurunathan S. Rapid biological synthesis of silver nanoparticles and their enhanced antibacterial effects against Escherichia fergusonii and Streptococcus mutans. Arab J Chem 2019; 12(2): 168-80. doi: 10.1016/j.arabjc.2014.11.014
  40. Jeyaraj M, Sathishkumar G, Sivanandhan G, et al. Biogenic silver nanoparticles for cancer treatment: An experimental report. Colloids Surf B Biointerfaces 2013; 106: 86-92. doi: 10.1016/j.colsurfb.2013.01.027 PMID: 23434696
  41. Singh D, Yadav E, Falls N, Kumar V, Singh M, Verma A. RETRACTED ARTICLE: Phytofabricated silver nanoparticles of Phyllanthus emblica attenuated diethylnitrosamine-induced hepatic cancer via knock-down oxidative stress and inflammation. Inflammopharmacology 2019; 27(5): 1037-54. doi: 10.1007/s10787-018-0525-6 PMID: 30219979
  42. Manish P, Prateek P, Hrvoje R, et al. Attenuation of hepatic and breast cancer cells by Polygonatum verticillatum embedded silver nanoparticles. Biocatal Agric Biotechnol 2020; 30: 1-33.
  43. Sarkar S, Kotteswaran V. Green Synthesis of silver nanoparticles from aqueous leaf extract of pomegranate (Punica granatum) and their anti-cancer activity on human cervical cancer cells. Adv Nat Sci: Nanosci Nanotechnol 2018; 9(2): 025014.
  44. Vlasceanu GM, Marin S, Elena R, et al. Silver Nanoparticles in Cancer Therapy Nanobiomaterials in Cancer Therapy. Amsterdam: Elsevier Inc. 2016; pp. 29-56. doi: 10.1016/B978-0-323-42863-7.00002-5
  45. Shaalan M, El-Mahdy M, Theiner S, Dinhopl N, El-Matbouli M, Saleh M. Silver nanoparticles: Their role as antibacterial agent against Aeromonas salmonicida subsp. salmonicida in rainbow trout (Oncorhynchus mykiss). Res Vet Sci 2018; 119: 196-204. doi: 10.1016/j.rvsc.2018.06.019 PMID: 29958154
  46. Franci G, Falanga A, Galdiero S, et al. Silver nanoparticles as potential antibacterial agents. Molecules 2015; 20(5): 8856-74. doi: 10.3390/molecules20058856 PMID: 25993417
  47. Khandelwal N, Kaur G, Kumar N, Tiwari A. Application of silver nanoparticles in viral inhibition: A new hope for antivirals. Dig J Nanomater Biostruct 2014; 9(1): 175-86.
  48. El-Rafie HM, Manal AH. Antioxidant and anti-inflammatory activities of silver nanoparticles biosynthesized from aqueous leaves extracts of four terminalia species. Adv Nat Sci: Nanosci Nanotechnol 2014; 5(3): 035008.
  49. Singh K, Niraimathik L, Arunk P, Narendran R, Balaji K, Brindha P. In-Vitro Anti-Inflammatory Studies on Silver Nanoparticles Synthesized from Centratherum punctatum cass. Int J Res Ayurveda Pharm 2016; 7(2): 61-6. doi: 10.7897/2277-4343.07258
  50. Mahalakshmi K, Thabitha LP. Synthesis and antioxidative study of silver nanoparticles using Lactobacillus species isolated from breast milk. Chettinad Health City Med J 2020; 9(2): 82-7.
  51. Qureshi AT. Silver nanoparticles as multi-functional drug delivery systems. London, UK: IntechOpen 2013.
  52. Ivanova N, Gugleva V, Dobreva M, Pehlivanov I, Stefanov S, Andonova V. Silver nanoparticles as multi-functional drug delivery systems. London: IntechOpen 2018.
  53. Balan K, Qing W, Wang Y, et al. Antidiabetic activity of silver nanoparticles from green synthesis using Lonicera japonica leaf extract. RSC Advances 2016; 6(46): 40162-8. doi: 10.1039/C5RA24391B
  54. Silver nanoparticles elevates wound healing. 2010. Available From: https://www.biotecharticles.com/Nanotechnology-Article/Silver-Nanoparticles-Elevates-Wound-Healing-238.html
  55. Yates KM, Proctor CA, Atchley DH. Antimicrobial silver hydrogel composition for the treatment of burns and wounds. US Patent 9327029 2016.
  56. Zhang R, Lee P, Lui VCH, et al. Silver nanoparticles promote osteogenesis of mesenchymal stem cells and improve bone fracture healing in osteogenesis mechanism mouse model. Nanomedicine 2015; 11(8): 1949-59. doi: 10.1016/j.nano.2015.07.016 PMID: 26282383
  57. Bharti A, Singh S, Meena VK, Goyal N. Structural characterization of silver-hydroxyapatite nanocomposite: A bone repair biomaterial. Mater Today Proc 2016; 3(6): 2113-20. doi: 10.1016/j.matpr.2016.04.116
  58. Silver nanoparticles help cure hard to treat mouth infections. 2012. Available From: https//www.wiley.com
  59. Butrón Téllez Girón C, Hernández Sierra JF, DeAlba-Montero I, Urbano Peña MA, Ruiz F. Therapeutic use of silver nanoparticles in the prevention and arrest of dental caries. Bioinorg Chem Appl 2020; 2020: 1-7. doi: 10.1155/2020/8882930
  60. Lohani A, Verma A, Joshi H, Yadav N, Karki N. Nanotechnology-based cosmeceuticals. ISRN Dermatol 2014; 2014: 1-14. doi: 10.1155/2014/843687 PMID: 24963412
  61. Yavitz EQ, Posteraro L. Silver nanoparticles for treating eyelash and eyelid margin infections. U.S. Patent 9095566, 2015.
  62. Tan P, Li H, Wang J, Gopinath SCB. Silver nanoparticle in biosensor and bioimaging: Clinical perspectives. Biotechnol Appl Biochem 2021; 68(6): 1236-42. PMID: 33043496
  63. Zhang M, Zhang K, De Gusseme B, Verstraete W, Field R. The antibacterial and anti-biofouling performance of biogenic silver nanoparticles by Lactobacillus fermentum. Biofouling 2014; 30(3): 347-57. doi: 10.1080/08927014.2013.873419 PMID: 24564796
  64. Zhang DY, Hao Q, Liu J, et al. Antifouling polyimide membrane with grafted silver nanoparticles and zwitterion. Separ Purif Tech 2018; 192: 230-9. doi: 10.1016/j.seppur.2017.10.018
  65. Ferdous Z, Nemmar A. Health impact of silver nanoparticles: A review of the biodistribution and toxicity following various routes of exposure. Int J Mol Sci 2020; 21(7): 2375. doi: 10.3390/ijms21072375 PMID: 32235542
  66. Elliott G. Basics of US Patents and the Patent System. AAPS J 2007; 9(3): E317-24.
  67. Yang J. Core Concept 7: The overall patent process and costs. Irvine, USA: OC Patent Lawyer 2018.
  68. Awad MAG, Alwehaibi MAR, Alshehri JH, Alkhulaifi MM, Aldosari NS, Ortashi KMO. Method of producing silver nanoparticles using red sand U.S. Patent 10751802, 2020.
  69. Farrugia VM, Keoshkerian B, Chretien MN. Polymer coated sulfonated polyester silver nanoparticle composite filaments and methods of making the same E.P. Patent 3231900, 2018.
  70. Ostrum R, Hettinger J, Krchnavek R, Caputo GA. Use of silver containing layers at implant surfaces U.S. Patent 9649338, 2017.
  71. Alsharaeh EH, Aldosari MA, Othman AARM, Al-Hindawi MFQ, Alsaud KBB. Anti-microbial polymer-graphene-silver nanocomposite U.S. Patent 9334386, 2015.
  72. Atta AM, Al-Lohedan HA, Ezzat AO. Method of synthesizing silver nanoparticles from waste film U.S. Patent 9347114, 2016.
  73. Zboril R, Soukupova J. Method of immobilization of silver nanoparticles on solid substrates U.S. Patent 9505027, 2015.
  74. Davis F, Atkinson A, Atkinson E. Lozenges with silver nanoparticles U.S. Patent 20150174079, 2015.
  75. Zhang J, Shachaf C. Methods of making silver nanoparticles and their applications U.S. Patent 10064793, 2015.
  76. Okamoto K, Koduma H. Method for producing silver nanoparticle, silver nanoparticle and silver coating composition U.S. Patent 9656322, 2015.
  77. Mousa SA, Linhardt RJ. Silver nanoparticles as anti-microbial U.S. Patent 8314078, 2012.
  78. Li Y. Silver nanoparticle process U.S. Patent 8382878, 2010.
  79. Yang SY. Procedure for preparation of functional microcapsules that include silver nanoparticles E.S. Patent 2311640, 2009.
  80. Sato K, Okano T. Method for producing silver nanoparticle J.P. Patent 2009102716, 2009.
  81. Windt WD, Wambeke MV, Verstraete W, Boon N. Silver nanoparticles with specific surface area and a method for producing them WIPO (PCT) Patent 2009087122, 2009.
  82. Ma RH, Yu YH. Nano-silver wound dressing U.S. Patent 7462753, 2008.
  83. Pratibha O. Silver nanoparticle dispersion formulation WIPO (PCT) Patent 2007017901, 2007.
  84. Gillis SH, Schechter P, Stiles JAR. Metal containing materials U.S. Patent 7255881, 2007.
  85. Kozlowski R, Laszkiewicz B, Kulpinski P, et al. Method of manufacturing silver nanoparticles, cellulosic fibres and nanofibers containing silver nanoparticles, fibres and nanofibers containing silver nanoparticles, use of silver nanoparticles to the manufacture of cellulosic fibres and nanofibers, and wound dressing containing silver nanoparticles E.P. Patent 2126146, 2007.
  86. Yacaman MJ, Elechiguerra JL, Burt JL, Morones JR, Larios L. Glycerine based synthesis of silver nanoparticles and nanowires WIPO (PCT) Patent 2007001453, 2009.
  87. Yang WD. Medical needles having antibacterial and painless function WIPO (PCT) Patent 2006088288, 2006.
  88. Examining Metastatic Non-Small Cell Lung Cancer 2021. Available From: https://www.medicalnewstoday.com/articles/323701
  89. Shrivastava S, Bera T, Roy A, Singh G, Ramachandrarao P, Dash D. Retracted: Characterization of enhanced antibacterial effects of novel silver nanoparticles. Nanotechnology 2007; 18(22): 225103. doi: 10.1088/0957-4484/18/22/225103 PMID: 37016550

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