Biological Potential and Therapeutic Effectiveness of Artemetin from Traditional to Modern Medicine: An Update on Pharmacological Activities and Analytical Aspects


Cite item

Full Text

Abstract

Background::Background: Plant products derived from natural sources have been used in medicine as a raw material and newer kinds of drug molecules in pharmaceuticals and other allied health sectors. Phytochemicals have numerous medicinal potentials, including anti- ageing, anti-carcinogenic, anti-microbial, anti-oxidant, and anti-inflammatory activity in medicine. Development and biological application of herbal products in modern medicine signified the value of traditional medicinal plants in health care systems.

Methods::The objective of the present study was to explore the scientific knowledge of the medicinal importance and therapeutic potential of artemetin in medicine. However, scientific investigations for their pharmacological activities in medicine have been done through scientific data analysis of different scientific research work collected from PubMed, Google, Science Direct and Google Scholar in order to know the biological importance of artemetin in medicine. Moreover, analytical data of artemetin have also been discussed in the present work.

Results::The present work scientific data signified the biological potential of artemetin in medicine. Artemetin has been derived from numerous medicinal plants and dietary herbs, including Artemisia absinthium, Artemisia argyi, Achillea millefolium, and Vitex trifolia. Artemetin has anti-malarial, anti-oxidant, anti-apoptotic, anti-microbial, anti-tumoral, antiatherosclerotic, anti-inflammatory, hypotensive and hepatoprotective effects. Further, the biological role of artemetin on lipid oxidation, cytokine production, lipoxygenase, and estrogen- like effects was also investigated in the present work. Analytical data on artemetin in the present paper signified their important role in the isolation, separation, and identification of different classes of pure phytochemicals, including artemetin in medicine.

Conclusion::Scientific data analysis of artemetin signified its therapeutic potential in medicine for the development of newer scientific approaches for different human disorders.

About the authors

Kanika Patel

Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture

Email: info@benthamscience.net

Dinesh Patel

Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture

Author for correspondence.
Email: info@benthamscience.net

References

  1. Patel K, Kumar V, Verma A, Rahman M, Patel DK. β-sitosterol: Bioactive compounds in foods, their role in health promotion and disease prevention "a concise report of its phytopharmaceutical importance. Curr Tradit Med 2017; 3(3): 168-77. doi: 10.2174/2215083803666170615111759
  2. Patel DK. Therapeutic effectiveness of magnolin on cancers and other human complications. Pharmacol Res - Mod Chinese Med 2023; 6: 100203.
  3. Patel DK. Biological importance and therapeutic potential of Trilobatin in the management of human disorders and associated secondary complications. Pharmacol Res - Mod Chinese Med 2022; 5: 100185.
  4. Patel DK. Biological potential and therapeutic benefit of Chrysosplenetin: An Applications of polymethoxylated flavonoid in medicine from natural sources. Pharma Res - Mod Chi Med 2022; 4: 100155. doi: 10.1016/j.prmcm.2022.100155
  5. Pate DK. Therapeutic role of columbianadin in human disorders: Medicinal importance, biological properties and analytical aspects. Pharmacol Res - Mod Chinese Med 2023; 6: 100212.
  6. Patel DK. Grandisin and its therapeutic potential and pharmacological activities: A review. Pharmacol Res - Mod Chinese Med 2022; 5: 100176.
  7. Rosa A, Isola R, Pollastro F, Nieddu M. Effect of the natural polymethoxylated flavone artemetin on lipid oxidation and its impact on cancer cell viability and lipids. Fitoterapia 2022; 156: 105102. doi: 10.1016/j.fitote.2021.105102 PMID: 34921927
  8. Qadir M, Dangroo NA, Agnihotri VK, Shah WA. Isolation, characterisation, antifungal activity and validated UPLC/MS/MS method for quantification of novel compound from Artemisia tournefortiana Reichb. Nat Prod Res 2021; 1-11. PMID: 33951993
  9. Fernandes ES, Passos GF, Medeiros R, et al. Anti-inflammatory effects of compounds alpha-humulene and (−)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea. Eur J Pharmacol 2007; 569(3): 228-36. doi: 10.1016/j.ejphar.2007.04.059 PMID: 17559833
  10. Salamone S, Nieddu M, Khalili A, et al. Effects of quercetin and artemetin prenylation on bioavailability and bioactivity. Chem Phys Lipids 2021; 240: 105137. doi: 10.1016/j.chemphyslip.2021.105137 PMID: 34529978
  11. Baraldi R, Isacchi B, Predieri S, Marconi G, Vincieri FF, Bilia AR. Distribution of artemisinin and bioactive flavonoids from Artemisia annua L. during plant growth. Biochem Syst Ecol 2008; 36(5-6): 340-8. doi: 10.1016/j.bse.2007.11.002
  12. Langa E, Pardo JI, Giménez-Rota C, González-Coloma A, Hernáiz MJ, Mainar AM. Supercritical anti-solvent fractionation of Artemisia absinthium L. conventional extracts: tracking artemetin and casticin. J Supercrit Fluids 2019; 151: 15-23. doi: 10.1016/j.supflu.2019.05.003
  13. Nagy C, Pesti A, Andrási M, Vasas G, Gáspár A. Determination of artemisinin and its analogs in Artemisia annua extracts by capillary electrophoresis- Mass spectrometry. J Pharm Biomed Anal 2021; 202: 114131. doi: 10.1016/j.jpba.2021.114131 PMID: 34023721
  14. Wang S, Cai T, Liu H, Yang A, Xing J. Liquid chromatography‐tandem mass spectrometry assay for the simultaneous determination of three major flavonoids and their glucuronidated metabolites in rats after oral administration of Artemisia annua L. extract at a therapeutic ultra‐low dose. J Sep Sci 2019; 42(21): 3330-9. doi: 10.1002/jssc.201900668 PMID: 31483950
  15. Han X, He J, Chen Q, et al. Development of an LC‐MS/MS‐based assay to determine artemitin in rat plasma and its application in a pharmacokinetic study. Biomed Chromatogr 2018; 32(12): e4356. doi: 10.1002/bmc.4356 PMID: 30073671
  16. de Almeida LMS, Carvalho LSA, Gazolla MC, et al. Flavonoids and sesquiterpene lactones from Artemisia absinthium and tanacetum parthenium against Schistosoma mansoni Worms. Evid Based Complement Alternat Med 2016; 2016: 1-9. doi: 10.1155/2016/9521349 PMID: 27980595
  17. Ortiz S, Dali-Yahia K, Vasquez-Ocmin P, et al. Heme-binding activity of methoxyflavones from Pentzia monodiana Maire (Asteraceae). Fitoterapia 2017; 118: 1-5. doi: 10.1016/j.fitote.2017.01.012 PMID: 28167052
  18. Sichaem J, Nguyen HH, Nguyen VH, et al. A new labdane-type diterpenoid from the leaves of Vitex negundo L. Nat Prod Res 2021; 35(14): 2329-34. doi: 10.1080/14786419.2019.1672687 PMID: 31583894
  19. Liu KCS, Yang SL, Roberts MF, Elford BC, Phillipson JD. Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. Plant Cell Rep 1992; 11(12): 637-40. doi: 10.1007/BF00236389 PMID: 24213368
  20. Elford BC, Roberts MF, Phillipson JD, Wilson RJM. Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. Trans R Soc Trop Med Hyg 1987; 81(3): 434-6. doi: 10.1016/0035-9203(87)90161-1 PMID: 3318019
  21. Ortet R, Prado S, Regalado EL, et al. Furfuran lignans and a flavone from Artemisia gorgonum Webb and their in vitro activity against Plasmodium falciparum. J Ethnopharmacol 2011; 138(2): 637-40. doi: 10.1016/j.jep.2011.09.039 PMID: 21982788
  22. Zheng GQ. Cytotoxic terpenoids and flavonoids from Artemisia annua. Planta Med 1994; 60(1): 54-7. doi: 10.1055/s-2006-959408 PMID: 8134418
  23. Sánchez I, Calderón J, Ruiz B, Tellez J, Calzada L, Taboada J. In vitro cytotoxicity of flavonoids against MK2 and C6 tumour cells. Phytother Res 2001; 15(4): 290-3. doi: 10.1002/ptr.954 PMID: 11406849
  24. Ko WG, Kang TH, Lee SJ, et al. Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells. Food Chem Toxicol 2000; 38(10): 861-5. doi: 10.1016/S0278-6915(00)00079-X PMID: 11039319
  25. Li WX, Cui CB, Cai B, Wang HY, Yao XS. Flavonoids from Vitex trifolia L. inhibit cell cycle progression at G2/M phase and induce apoptosis in mammalian cancer cells. J Asian Nat Prod Res 2005; 7(4): 615-26. doi: 10.1080/10286020310001625085 PMID: 16087636
  26. Kobayakawa J, Satonishimori F, Moriyasu M, Matsukawa Y. G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.). Cancer Lett 2004; 208(1): 59-64. doi: 10.1016/j.canlet.2004.01.012 PMID: 15105046
  27. Martins A, Mignon R, Bastos M, et al. In vitro antitumoral activity of compounds isolated from Artemisia gorgonum Webb. Phytother Res 2014; 28(9): 1329-34. doi: 10.1002/ptr.5133 PMID: 24633846
  28. Kim YA, Kim H, Seo Y. Antiproliferative effect of flavonoids from the halophyte Vitex rotundifolia on human cancer cells. Sage Journals Home 2013. doi: 10.1177/1934578X1300801016
  29. Csupor-Löffler B, Hajdú Z, Zupkó I, et al. Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. Phytother Res 2009; 23(5): 672-6. doi: 10.1002/ptr.2697 PMID: 19107850
  30. Sridevi VK, Chouhan HS, Singh NK, Singh SK. Antioxidant and hepatoprotective effects of ethanol extract of Vitex glabrata on carbon tetrachloride-induced liver damage in rats. Nat Prod Res 2012; 26(12): 1135-40. doi: 10.1080/14786419.2011.560849 PMID: 22054305
  31. Dugas AJ Jr, Castañeda-Acosta J, Bonin GC, Price KL, Fischer NH, Winston GW. Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: Structure-activity relationships. J Nat Prod 2000; 63(3): 327-31. doi: 10.1021/np990352n PMID: 10757712
  32. de Souza P, Gasparotto A Jr, Crestani S, et al. Hypotensive mechanism of the extracts and artemetin isolated from Achillea millefolium L. (Asteraceae) in rats. Phytomedicine 2011; 18(10): 819-25. doi: 10.1016/j.phymed.2011.02.005 PMID: 21420289
  33. Choudhary MI, Azizuddin , Jalil S, et al. Antiinflam-matory and lipoxygenase inhibitory compounds from vitex agnus-castus. Phytother Res 2009; 23(9): 1336-9. doi: 10.1002/ptr.2639 PMID: 19173281
  34. Sertié J, Basile A, Panizza S, Matida A, Zelnik R. Anti-inflammatory activity and sub-acute toxicity of artemetin. Planta Med 1990; 56(1): 36-40. doi: 10.1055/s-2006-960879 PMID: 2356241
  35. Bayeux MC, Fernandes AT, Foglio MA, Carvalho JE. Evaluation of the antiedematogenic activity of artemetin isolated from Cordia curassavica DC. Braz J Med Biol Res 2002; 35(10): 1229-32. doi: 10.1590/S0100-879X2002001000017 PMID: 12424497
  36. Kim JY, Shim SH. Anti-atherosclerotic effects of fruits of vitex rotundifolia and their isolated compounds via inhibition of human LDL and HDL Oxidation. Biomolecules 2019; 9(11): 727. doi: 10.3390/biom9110727 PMID: 31726713
  37. Lee JH, Lee S, Nguyen QN, et al. Identification of the active ingredient and beneficial effects of vitex rotundifolia fruits on menopausal symptoms in ovariectomized rats. Biomolecules 2021; 11(7): 1033. doi: 10.3390/biom11071033 PMID: 34356661
  38. Wee HN, Neo SY, Singh D, et al. Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages. BMC Complemen Med Ther 2020; 20(1): 91. doi: 10.1186/s12906-020-02884-w PMID: 32188443
  39. Lee D, Kim CE, Park SY, et al. Protective effect of artemisia argyi and its flavonoid constituents against contrast-induced cytotoxicity by iodixanol in LLC-PK1 cells. Int J Mol Sci 2018; 19(5): 1387. doi: 10.3390/ijms19051387 PMID: 29735908
  40. Grossini E, Marotta P, Farruggio S, et al. Effects of artemetin on nitric oxide release and protection against peroxidative injuries in porcine coronary artery endothelial cells. Phytother Res 2015; 29(9): 1339-48. doi: 10.1002/ptr.5386 PMID: 26032176
  41. Martim JKP, Maranho LT, Costa-Casagrande TA. Review: Role of the chemical compounds present in the essential oil and in the extract of Cordia verbenacea DC as an anti-inflammatory, antimicrobial and healing product. J Ethnopharmacol 2021; 265: 113300. doi: 10.1016/j.jep.2020.113300 PMID: 32871237
  42. Amadi PU, Agomuo EN, Adumekwe CW. Modulatory properties of cardiac and quercetin glycosides from Dacryodes edulis seeds during L-NAME-induced vascular perturbation. J Basic Clin Physiol Pharmacol 2020; 31(5): 20190116. doi: 10.1515/jbcpp-2019-0116 PMID: 32653874
  43. Ifeanacho MO, Ikewuchi CC, Ikewuchi JC. Investigation of the profile of phenolic compounds in the leaves and stems of Pandiaka heudelotii using gas chromatography coupled with flame ionization detector. Food Sci Nutr 2017; 5(3): 646-52. doi: 10.1002/fsn3.443 PMID: 28572953
  44. Sharma N, Kumar C, Dutt P, et al. Isolation, chemical fingerprinting and simultaneous quantification of four compounds from tanacetum gracile using a validated HPLC–ESI-QTOF-mass spectrometry method. J Chromatogr Sci 2016; 54(5): 796-804. doi: 10.1093/chromsci/bmw013 PMID: 26951542
  45. Chen XQ, Wang M, Zhang X, Guo WW, Wu X. Study on chemical constituents of Achillea alpina. Zhongguo Zhongyao Zazhi 2015; 40: 1330-3.
  46. Zheng LH, Hao XJ, Yuan CM, et al. (Study on chemical constituents of Inula cappa). Zhongguo Zhongyao Zazhi 2015; 40(4): 672-8. (Study on chemical constituents of Inula cappa). PMID: 26137689
  47. Suberu JO, Yamin P, Leonhard K, et al. The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin. J Biotechnol 2014; 171: 25-33. doi: 10.1016/j.jbiotec.2013.11.024 PMID: 24333126
  48. Cui F-X, Zhang C, Jiang Y, Tu P-F. (Chemical constituents from ethyl acetate extract of Artemisia rupestris). Zhongguo Zhongyao Zazhi 2013; 38(11): 1757-9. PMID: 24010291
  49. Li S, Qiu S, Yao P, Sun H, Fong HHS, Zhang H. Compounds from the fruits of the popular european medicinal plant vitex agnus-castus in chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction. Evid Based Complement Alternat Med 2013; 2013: 432829. PMID: 23662135
  50. Weathers P, Towler M. The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion. Planta Med 2012; 78(10): 1024-6. doi: 10.1055/s-0032-1314949 PMID: 22673829
  51. Liu YW, Cheng YB, Liaw CC, et al. Bioactive diterpenes from callicarpa longissima. J Nat Prod 2012; 75(4): 689-93. doi: 10.1021/np200932k PMID: 22429052
  52. Guan R, Wang D, Yu Z, Wang X, Lan T. Preparative isolation and purification of the active components from Viticis Fructus by high-speed counter-current chromatography. Se Pu 2010; 28(11): 1043-7. PMID: 21381420
  53. Hussain J, Khan FU, Rehman NU, et al. One new triterpene ester from Nepeta suavis. J Asian Nat Prod Res 2009; 11(12): 997-1000. doi: 10.1080/10286020903264085 PMID: 20183267
  54. Michielin EMZ, Salvador AA, Riehl CAS, Smânia A Jr, Smânia EFA, Ferreira SRS. Chemical composition and antibacterial activity of Cordia verbenacea extracts obtained by different methods. Bioresour Technol 2009; 100(24): 6615-23. doi: 10.1016/j.biortech.2009.07.061 PMID: 19683436
  55. Shi S, Honghao Z, Zhang Y, Zhao Y, Kelong H, Liu S. A high-speed counter-current chromatography- HPLC-DAD method for preparative isolation and purification of two polymethoxylated flavones from Taraxacum mongolicum. J Chromatogr Sci 2009; 47(5): 349-53. doi: 10.1093/chromsci/47.5.349 PMID: 19476701
  56. Shi S-Y, Zhou C-X, Xu Y, et al. Studies on chemical constituents from herbs of Taraxacum mongolicum. Zhongguo Zhongyao Zazhi 2008; 33(10): 1147-57. PMID: 18720865
  57. Yao W, Lin W-Y, Zhou C-X, Zhao Y. Studies on constitutes from Taraxacum mongolicum. Zhongguo Zhongyao Zazhi 2007; 32(10): 926-9. PMID: 17655148
  58. Yoshioka T, Inokuchi T, Fujioka S, Kimura Y. Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia. Z Naturforsch C J Biosci 2004; 59(7-8): 509-14. doi: 10.1515/znc-2004-7-810 PMID: 15813370
  59. Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T. New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. J Nat Prod 2002; 65(4): 537-41. doi: 10.1021/np0105331 PMID: 11975496
  60. Tang H, Hu J, Yang L, Tan R. Terpenoids and flavonoids from Artemisia species. Planta Med 2000; 66(4): 391-3. doi: 10.1055/s-2000-8538 PMID: 10865468
  61. Ahmed D, Choudhary M, Turkoz S, Sener B. Chemical constituents of buxus sempervirens. Planta Med 1988; 54(2): 173-4. doi: 10.1055/s-2006-962384 PMID: 17265235
  62. Falk AJ, Smolenski SJ, Bauer L, Bell CL. Isolation and identification of three new flavones from Achillea millefolium L. J Pharm Sci 1975; 64(11): 1838-42. doi: 10.1002/jps.2600641119 PMID: 1195115
  63. Tasdemir D, Tierney M, Sen R, et al. Antiprotozoal effect of artemisia indica extracts and essential oil. Planta Med 2015; 81(12/13): 1029-37. doi: 10.1055/s-0035-1546125 PMID: 26085047
  64. Lan JE, Li XJ, Zhu XF, et al. Flavonoids from Artemisia rupestris and their synergistic antibacterial effects on drug-resistant Staphylococcus aureus. Nat Prod Res 2021; 35(11): 1881-6. doi: 10.1080/14786419.2019.1639182 PMID: 31303068
  65. Sinha S, Amin H, Nayak D, et al. Assessment of microtubule depolymerization property of flavonoids isolated from Tanacetum gracile in breast cancer cells by biochemical and molecular docking approach. Chem Biol Interact 2015; 239: 1-11. doi: 10.1016/j.cbi.2015.06.034 PMID: 26115782
  66. Hirobe C, Qiao ZS, Takeya K, Itokawa H. Cytotoxic flavonoids from Vitex agnus-castus. Phytochemistry 1997; 46(3): 521-4. doi: 10.1016/S0031-9422(97)00127-1 PMID: 9332026

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2024 Bentham Science Publishers