Enviar artigo por via de e-mail Effect of nanocluster polyoxometalate {mo72fe30} on morphofunctional state of macrophages in cultures
- Autores: Titova S.A.1, Tonkushina M.O.1, Grzhegorzhevskii K.V.1, Danilova I.G.1,2, Pozdina V.A.2, Ulitko M.V.1, Ostroushko A.A.1
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Afiliações:
- Ural Federal University named after the First President of Russia B. N. Yeltsin
- Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
- Edição: Volume 66, Nº 4 (2024)
- Páginas: 367-379
- Seção: Articles
- URL: https://rjonco.com/0041-3771/article/view/669501
- DOI: https://doi.org/10.31857/S0041377124040053
- EDN: https://elibrary.ru/QCQFVM
- ID: 669501
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Resumo
The aim of this work was to study the effect of nanocluster polyoxometalate {Mo72Fe30} on the macrophage link of the immune system. In vitro studies of polyoxometalate on macrophage cultures allowed us to evaluate the reaction of immune system cells (in particular, peritonial and alveolar macrophages) to nanoparticles. The analysis of the obtained data allowed to establish that {Mo72Fe30} is not toxic for peritonial and alveolar macrophages, has no significant effect on the morphology of cells, as well as on the activity of α-naphthylacetate esterase. However, it significantly reduces phagocytic activity when cells are cultured with POM, which may indicate possible polarisation of macrophages. The obtained results confirm the possibility of using {Mo72Fe30} in the field of biomedicine.
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Sobre autores
S. Titova
Ural Federal University named after the First President of Russia B. N. Yeltsin
Autor responsável pela correspondência
Email: svetattitova12021998@gmail.com
Rússia, Ekaterinburg
M. Tonkushina
Ural Federal University named after the First President of Russia B. N. Yeltsin
Email: svetattitova12021998@gmail.com
Rússia, Ekaterinburg
K. Grzhegorzhevskii
Ural Federal University named after the First President of Russia B. N. Yeltsin
Email: svetattitova12021998@gmail.com
Rússia, Ekaterinburg
I. Danilova
Ural Federal University named after the First President of Russia B. N. Yeltsin; Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
Email: svetattitova12021998@gmail.com
Rússia, Ekaterinburg; Ekaterinburg
V. Pozdina
Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
Email: svetattitova12021998@gmail.com
Rússia, Ekaterinburg
M. Ulitko
Ural Federal University named after the First President of Russia B. N. Yeltsin
Email: svetattitova12021998@gmail.com
Rússia, Ekaterinburg
A. Ostroushko
Ural Federal University named after the First President of Russia B. N. Yeltsin
Email: svetattitova12021998@gmail.com
Rússia, Ekaterinburg
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