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Effect of nanocluster polyoxometalate {mo72fe30} on morphofunctional state of macrophages in cultures
- Authors: Titova S.A.1, Tonkushina M.O.1, Grzhegorzhevskii K.V.1, Danilova I.G.1,2, Pozdina V.A.2, Ulitko M.V.1, Ostroushko A.A.1
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Affiliations:
- Ural Federal University named after the First President of Russia B. N. Yeltsin
- Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
- Issue: Vol 66, No 4 (2024)
- Pages: 367-379
- Section: Articles
- URL: https://rjonco.com/0041-3771/article/view/669501
- DOI: https://doi.org/10.31857/S0041377124040053
- EDN: https://elibrary.ru/QCQFVM
- ID: 669501
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Abstract
The aim of this work was to study the effect of nanocluster polyoxometalate {Mo72Fe30} on the macrophage link of the immune system. In vitro studies of polyoxometalate on macrophage cultures allowed us to evaluate the reaction of immune system cells (in particular, peritonial and alveolar macrophages) to nanoparticles. The analysis of the obtained data allowed to establish that {Mo72Fe30} is not toxic for peritonial and alveolar macrophages, has no significant effect on the morphology of cells, as well as on the activity of α-naphthylacetate esterase. However, it significantly reduces phagocytic activity when cells are cultured with POM, which may indicate possible polarisation of macrophages. The obtained results confirm the possibility of using {Mo72Fe30} in the field of biomedicine.
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About the authors
S. A. Titova
Ural Federal University named after the First President of Russia B. N. Yeltsin
Author for correspondence.
Email: svetattitova12021998@gmail.com
Russian Federation, Ekaterinburg
M. O. Tonkushina
Ural Federal University named after the First President of Russia B. N. Yeltsin
Email: svetattitova12021998@gmail.com
Russian Federation, Ekaterinburg
K. V. Grzhegorzhevskii
Ural Federal University named after the First President of Russia B. N. Yeltsin
Email: svetattitova12021998@gmail.com
Russian Federation, Ekaterinburg
I. G. Danilova
Ural Federal University named after the First President of Russia B. N. Yeltsin; Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
Email: svetattitova12021998@gmail.com
Russian Federation, Ekaterinburg; Ekaterinburg
V. A. Pozdina
Institute of Immunology and Physiology, Urals Branch, Russian Academy of Sciences
Email: svetattitova12021998@gmail.com
Russian Federation, Ekaterinburg
M. V. Ulitko
Ural Federal University named after the First President of Russia B. N. Yeltsin
Email: svetattitova12021998@gmail.com
Russian Federation, Ekaterinburg
A. A. Ostroushko
Ural Federal University named after the First President of Russia B. N. Yeltsin
Email: svetattitova12021998@gmail.com
Russian Federation, Ekaterinburg
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