On phosphine-containing gold(I) complexes in solutions in connection with their biological applications

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Abstract

Some transformations involving AuCl(PPh3) in CH3CN/H2O solution are considered and a comparison is made with known data for auranofin. Interaction with GSH leads to the formation of a binuclear (GSH)[Au(PPh3)]2 (at CGSH/CAu < 0.5) or mononuclear Au(GSH)(PPh3) (CGSH/CAu > 0.5) complex; PPh3 substitution is not observed. Interaction with BSA leads to Cl– substitution. A cyclic voltammetry study showed the presence of several peaks of irreversible oxidation of AuCl(PPh3) and complexes with GSH.

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About the authors

I. V. Mironov

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Author for correspondence.
Email: imir@niic.nsc.ru
Russian Federation, Novosibirsk, 630090

V. Y. Kharlamova

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Email: imir@niic.nsc.ru
Russian Federation, Novosibirsk, 630090

D. B. Kal’nyi

Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences

Email: imir@niic.nsc.ru
Russian Federation, Novosibirsk, 630090

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Supplementary files

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2. Fig. 1. Change in the UV spectrum of AuCl(PPh3) solution in 50% AN with the addition of GSH (pH 7.4, l = 1 cm). CAu = 1.34 × 10-4 M, CGSH (10-5 M): 0 (1); 3.2 (2); 6.4 (3); 9.6 (4); 12.8–230 (5). Spectrum 6 – PPh3 (9.11 × 10-5 M) (a). Change in A/lCAu at λ = 260 nm. CAu (10-4 M): 1.34 (Δ), 0.52 (O). 1 is the calculated curve, 2 is the estimated change for mononuclear forms, 3 is the estimated change for the binuclear form, l = 1 cm (b).

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3. Fig. 2. The change in the UV spectrum of the solution during the interaction of AuCl(PPh3) with cysteine. CAu = 1.34 × 10-4 M, CCys (10-4 M): 0 (1); 0.35 (2); 0.67 (3); 1.0–12 (4). pH 7.4, 50% AN, l = 1 cm.

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4. Fig. 3. Color-grams of solutions containing AuCl(PPh3) (CAu = 1.0 × 10-3 M) and GSH. CGSH/CAu: 0 (1); 0.4/1 (2); 0.9/1 (3). Dependences (4) and (5) relate to solutions of GSH and PPh3 (C = 1.0 × 10-3 M). All solutions contain 0.1 M LiClO4, AN (80%), H2O (20%). a is 1 × 10-3 M HCl, b is 1 × 10-3 M HClO4. E relative to the Ag+/Ag electrode, the scanning speed is 100 mV/s.

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5. Fig. 4. Changes in UV spectra during the interaction of AuCl(PPh3) with BSA (1%) in AN (37%) in the presence of Cys (2.0 × 10-4 M). 1 – 1% BSA; 2 – 1% BSA + 1.0 × 10-4 M AuCl(PPh3) τ = 0; 3 – 1.0 × 10-4 M AuCl(PPh3) without BSA; 4-7 – A2–A1 difference spectra for τ (min) after mixing: 0 (4), 10 (5), 30 (6), 60 (7), l = 0.2 cm.

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6. Scheme 1.

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